Page 42 - Fpgee Question And Answer 2024 Edition

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965.(b) Adrenaline is the principal secretion of the Quetiapine (Seroquel) is indicated for the treatment
medulla of the suprarenal gland. It produces a of psychotic disorder. NMS, orthostatic
number of pharmacological actions in the body. hypotension, tardive dyskinesia and cataract
formation are reported side effects of the drug. The
1. It increases the force of contraction and rate of recommended dose is 300 mg to 400 mg per day in
the heart. two to three divided doses.
2. It relaxes bronchial smooth muscles.
3. It converts glycogen into glucose in the liver. 970. (b) Goserelin (Zoladex) is a synthetic analogue
4. It also increases the coagulation process. of LHRH. It acts as a potent inhibitor of pituitary
gonadotropin secretion. It is indicated for the
966.(d) The recommended adult dose for H. pylori treatment of carcinoma of the prostate and breast,
infection is 20 mg Omeprazole, 500 mg and endometriosis. It is also indicated as an
Clarithromycin and 1000 mg Amoxicillin, each given endometrial thinning agent.
twice day for 10 days.
971. (a) Zolmitriptan (Zomig) is a 5-HT receptor
967.(b) Tocainide (Tonocard) is indicated for the agonist. It is indicated for the treatment of migraine
treatment of ventricular arrhythmia. with or without aura in adults. The recommended
Agranulocytosis, bone marrow suppression, dose is 1 mg to 1.25 mg at the onset of headache,
leukopenia, neutropenia, aplastic anemia, and if the headache returns, the dose may be
septicemia and septic shock have been reported repeated after 2 hours, not to exceed 10 mg within
with Tocainide. 24 hours.

Pulmonary fibrosis, interstitial pneumonitis, 972. (a,b and c) Zolmitriptan (Zomig) should be
fibrosing alveolitis, pulmonary edema and carefully prescribed to patients with hypertension
pneumonia have been reported with Tocainide. or ischemic heart disease. It should not be taken
with MAO inhibitors or ergot alkaloid containing
The recommended dose is 400 mg three times a products.
day.
973. (b) When Carbidopa and Levodopa tablets are
968. (b) Anastrozole (Arimidex) is indicated for the to be given to patients who are being treated with
treatment of breast cancer. It is a non-steroidal Levodopa, Levodopa therapy must be discontinued
aromatase inhibitor. 8 hours before therapy with the combination
product is initiated.
Many breast cancers have estrogen receptors, and
growth of these tumors can be stimulated by 974. (d) Pergolide mesylate (Permax) is indicated
estrogens such as extradiol. Aromatase enhances for the treatment of Parkinson’s disease. It is an
the conversion of andro testosterone to ergot derivative Dopamine receptor agonist. It is 10
testosterone; the former is a major source for to 1000 times more potent than Bromocriptine
estradiol. (Parlodel) on a milligram per milligram basis. The
normal recommended dose is 1 to 3 mg per day.
The recommended dose is 1-mg taken once a day.
975. (d) Tizanidine (Zanaflex) is a centrally acting
969. (b) Cataract formation is normally reported alpha-2 receptor agonist. It is indicated for the
with chronic use of Quetiapine (Seroquel). It is short-term treatment of spasticity. It presumably
recommended to examine the lens for cataract reduces spasticity by increasing presynaptic
formation at initiation and every six months inhibition of motor neurons.
thereafter during the therapy.

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