Page 39 - Fpgee Question And Answer 2024 Edition

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The recommended dose is 10mg per day in two Enzyme inducing drugs:
divided doses. Insomnia, tachycardia, CNS
stimulation, dizziness, fainting, nausea, and Carbamazepine Phenytoin
vomiting are reported side effects of the drug. Griseofulvin Rifabutin
Isoniazid Rifampin
941. (d) Zidovudine (Retrovir) was the first Phenobarbital
approved drug by the FDA for the treatment of HIV.
It is classified as an antiviral agent. Severe anemia, 945.(b) Linezolid (Zyvox) is a synthetic antibacterial
granulocytopenia, nausea, vomiting, and agent of the oxazolidinone class. It is indicated for
hepatomegaly with steatosis are reported side the treatment of Nosocomial pneumonia,
effects of the drug. The recommended dose is 100 Community-acquired pneumonia, skin and skin
mg every 4 hours. structure infections and Vancomycin-resistant
enterococcus faecium infections. The
942. (d) Flushing is the major complication of recommended dose is 400mg to 600mg every 12
Nicotinic acid (Niacin) therapy, and can be hours for 10 to 28 days. It is a reversible,
prevented by: nonselective inhibitor of monoamine oxidase.
Nausea, vomiting, diarrhea, headache and
I. Taking Niacin with food. thrombocytopenia are reported side effects of
II. Initiating therapy with a low dose of the drug. Linezolid (Zyvox).
III. Taking aspirin 30 minutes prior to Niacin.
946.(d) Erythromycin and other antibiotics may
943. (c) When a subject changes the posture from increase the absorption of Digoxin by reducing the
the lying down position to the upright, there is a normal GI flora in the stomach, which inactivates
reflex rise in blood pressure compensating a Digoxin prior to its absorption.
momentary hypotension. However many times
patients who are taking adrenergic blockers, this When Quinidine is used simultaneously with
hypotension remains for a sustained time after Digoxin, the serum concentration of Digoxin is
changing the posture. This is called postural normally raised.
hypotension.
Colestipol and Questran may reduce the absorption
944. (c) Carbamazepine (Tegretol) is an enzyme- of Digoxin by binding to the acidic moiety of
inducer drug. Other choices such as Cimetidine Digoxin. Also, Digoxin suppresses the A.V. node
(Tagamet), Fluoxetine (Prozac), Ciprofloxacin (Cipro) conduction.
and Amiodarone (Cordarone) are enzyme inhibitors.
They inhibit the metabolism and increase the Diltiazem and Verapamil both have negative effects
toxicity of other drugs. on A.V. node conduction, which results in
bradycardia when used concurrently with Digoxin.
Enzyme inhibiting drugs:
947.(d) Calcium acetate (PhosLo) is indicated for the
Amiodarone Diltiazem treatment of hyperphosphatemia. The
Fluvoxamine Cimetidine recommended dose is 2 tablets with each meal.
Erythromycin Ciprofloxacin Constipation, hypercalcemia, anorexia and nausea
Fluconazole Ketoconazole are reported side effects of the drug.
Metronidazole Clarithromycin
Fluoxetine Nefazodone 948. (c) A normal therapeutic range of Activated
Quinidine Valproic acid Partial Thromboplastin Time is 35 to 45 seconds.
Verapamil

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