Page 43 - Fpgee Question And Answer 2024 Edition

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It has a shorter duration of action. The 981. (a) Clomiphene (Clomid) is indicated for the
recommended dose is 4 to 6 mg as needed, not to treatment of ovulatory dysfunction in women
exceed a single dose more than 8 mg and a total during pregnancy. It is classified as an ovarian
daily dose more than 24 mg. stimulant agent. It combines with estrogen
receptors. Through negative feedback mechanism,
976. (a) Fexofenadine (Allegra) is an antihistamine the hypothalamus and pituitary are stimulated to
with selective peripheral H-1 receptor antagonists. increase secretion of FSH and LH. Under the
It is indicated for the relief of symptom associated influence of increased levels of these hormones, an
with seasonal allergic rhinitis in adults and children ovarian follicle develops, followed by ovulation and
6 years of age or older. The recommended dose is corpus luteum development.
60 mg twice daily or 180 mg once daily. The nasal
decongestant found in Allegra-D is Blurred vision, spots or flashes, posterior capsular
Pseudoephedrine. cataract, spasm of retinal arteriole, and uterine
bleeding are reported side effects of the drug. The
977. (c) Dolasetron (Anzemet) is indicated for the recommended dose is 50 mg per day for five days.
treatment of nausea and vomiting associated with
emetogenic cancer therapy. It is a selective 982. (b) Desmopressin (DDAVP) is a synthetic
serotonin 5 HT 3 receptor antagonist. It is available in analogue of the natural pituitary hormone. It is an
tablet and injection form. The recommended adult antidiuretic hormone affecting renal water
dose is 100 mg, 1 hour before chemotherapy. conservation. It is indicated for the treatment of
Hemophilia A, Von Willebrand’s disease and
978. (a) Dolasetron (Anzemet) should be Diabetes insipidus.
administered with caution in patients who have or
may develop prolonged cardiac conduction 983. (c) Insulin glargine (Lantus) is recombinant
intervals, particularly QTc. human insulin analog with a duration of action up
to 24 hours. It is produced by recombinant DNA
These include patients taking diuretics with a technology utilizing a nonpathogenic laboratory
potential for causing hypokalemia and strain of E. coli as the production organism. It must
hypomagnesemia, and patients taking anti- not be diluted or mixed with any other insulin
arrhythmic drugs or other drugs which lead to QT solution. It should be administered subcutaneously
prolongation. once a day at bed time. Hypoglycemia is the
principal side effects of the drug.
979. (b) Leflunomide (Arava) is an
immunomodulatory agent indicated for the 984. (b) The principal side effect of orally inhaled
treatment of rheumatoid arthritis. It inhibits corticosteroid is oral candidiasis. It can be
dihydroorotate dehydrogenase, an enzyme prevented by gargling with water after each
responsible for pyrimidine synthesis. The inhalation. Mycelex Troche (Clotrimazole) and
recommended dose is 20 mg per day. It must not be Nystatin Pastilles are drugs of choice for the
prescribed to pregnant women since it is classified treatment of oral candidiasis.
under Pregnancy Category-X.
985. (b) Nilutamide (Nilandron) is a nonsteroidal
980. (c) The most frequently reported side effect of orally active antiandrogen. It is indicated for the
Sucralfate (Carafate) is constipation. It is indicated treatment of metastatic prostate cancer. The
for the treatment of duodenal ulcers. The recommended dosage is six tablets (50 mg each)
recommended adult oral dosage for duodenal once a day for the total daily dose of 300 mg for 30
ulcers is 1 gm four times a day. days followed by three tablets (50 mg each) once a
day for a total daily dosage of 150 mg.

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