Page 38 - Fpgee Question And Answer 2024 Edition
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www.pharmacyexam.com Krisman
931. (d) In normal resting cardiac muscles, the 936. (d) Cimetidine (Tagamet) has profound CP450
membrane is positive outside with respect to inside. inhibition property that inhibits the metabolism of
This is because of a large concentration of sodium the number of drugs. It increases the toxicities of
ions that lie outside the membrane. The large Theophylline and Ketoconazole. Concurrent use
concentration of sodium ions outside is due to an with antacids and H 2-receptor antagonists may not
+ +
enzyme Na K ATP ase pump. be recommended since absorption of H 2 receptor
antagonists may be impaired by antacids. Patients
As the membrane gets excited, influx of sodium ions should be advised not to take any antacids within
and efflux of potassium ions occurs due to change 1/2 to 1 hour of taking any H 2-receptor antagonist.
in the permeability of cell membrane.
937. (a) Amlodipine (Norvasc) is classified as
The influx of sodium ions increases intracellular calcium channel blocker. It has the least incidence
calcium levels which then increases the contraction of reflex stimulation of the sympathetic nervous
of heart muscles. system and thus the least chance of producing
reflex tachycardia. It is indicated for the treatment
+ +
Digitalis inhibits the Na K ATP ase pump, this of hypertension and angina. The recommended
increases the influx of sodium ions and dose is 5 mg to 10 mg once daily. Hypotension,
subsequently intracellular calcium levels. This leads tachycardia, dizziness and edema are reported side
to increase the force of contractions of heart effects of the drug.
muscles in congestive heart failure (CHF) patients.
938. (b) Hepatic toxicity is commonly reported with
932. (d) Charcoal plus, Actidose with sorbitol use of Isoniazid and Phenelzine.
(activated Charcoal with sorbitol) and Actidose
Aqua (activated charcoal suspension) are indicated 939. (c) Methylphenidate (Ritalin) is generally
for the treatment of accidental overdose of metals indicated for the treatment of attention deficit
and drugs. hyperactivity disorder. It is available in 5, 10 and 20
mg of oral strengths. It is a schedule II controlled
933. (b) Calcium channel blockers are indicated for drug. It is also available in sustained release tablet
the treatment of angina because: form. Methylphenidate (Ritalin) has a mild central
nervous system stimulant property. Nervousness,
1. They reduce myocardial contraction ability. insomnia and anorexia are common adverse effects
2. They reduce the oxygen consumption of the reported with Ritalin. The recommended daily dose
heart. of Methylphenidate (Ritalin)is 20 to 30 mg, in 2 to 3
3. They increase coronary blood flow by producing divided doses. Methylphenidate (Ritalin) SR has
dilation of coronary blood vessels. duration of action up to 8 hours and is available in
20 mg of oral strength. Methylphenidate (Ritalin)
934. (c) Thiazide diuretics may stimulate the should be carefully prescribed with MAO inhibitors.
reabsorption of glucose from renal tubules and
raise the serum concentration of glucose. Insulin 940. (d) Severe hypertensive crisis is observed when
and oral sulfonylurea therapies need to be adjusted Meperidine, Fluoxetine or Tyramine is concurrently
for patients’ currently on thiazide diuretics therapy. prescribed with Selegiline. Concurrent use is strictly
prohibited.
935. (d) Weight loss is not the reported side effect
of vasodilator. Most vasodilators are associated Selegiline (Eldepryl) is classified as an MAO B
with hypotension, tachycardia, palpitation, edema, inhibitor. It is indicated for the treatment of
weight gain, and facial flushing. They lower blood Parkinson’s. It inhibits the metabolism of dopamine
pressure in normal and hypertensive subjects. They and increases its concentration at dopamine
are indicated for the treatment of hypertension. receptor sites.
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