Page 46 - Fpgee Question And Answer 2024 Edition
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            method for obtaining GFR.
                                                                  =   10 drops/cc
                     Cu x V                                       =   22.91 drops/2.291cc
            CrCl =               ℎ      
                   CCr x 1440                                     =   22.91 drops/min

            CrCl = creatinine clearance in ml/min                 1204. (b)  The  amount  of  sodium  hypochlorite  is
            V = 24-hour urine volume                              required to prepare 1000cc 0.25% solution:
            Cu= concentration of creatinine in urine in mg
            CCr= creatinine serum concentration in mg/dL            1000    0.25
                                                                  =     100     = 2.5           
            The concentration of creatinine in the urine is 100
            mg/dL and 1 dL = 100 cc, therefore                    We  have  5%  Dakin  (Sodium  hypochlorite)  solution
                                                                  in a stock, therefore:
            100cc   contain      100 mg creatinine
            1400 cc contain      ?                                  2.5    100
                                                                  =     5
               1400    100
            =             = 1400                          
                  100                                             = 50    , 5%              ℎ        ℎ                             

                   1400 x 1400 x 100                              1205. (b) The drug is decomposing according to first
            CrCl =
                        2 x 1440                                  order kinetic, therefore:

                   68055 ml        68055 ml                           2.303    Co
            CrCl =           =                                    t =        log     ℎ      
                      day      24 x 60 minutes                          k       C

                                                                                              -2
            CrCl =  47.26 ml/minute                               Co = original concentration = 10
                                                                                              -6
                                                                  C = concentration at time t = 10
                                                                                            -10
            1201. (b) 500cc, 5% Dextrose solutions shall          K = rate constant = 2.303 x 10
            contain:
                                                                          2.303        10 −2
            500    5                                              t =           −10   log  −6
                  = 25                                                2.303 x 10       10
             100
                                                                        1
                                                                                  4
            1202. (d) 1 in 100 solution is interpreted as 1 gram   t =   −10   log10
            of  drug  in  100cc of  solution.  We  want to  find  out      10
            how much atropine is required to dispense 1 quart           1
            (960cc) , 1 in 100 solution, therefore:               t =   10 −10   x 4

            960    1  = 9.6                             = 9600        t =  40 x 10  ℎ        
                                                                             9
             100

            1203. (d) 22.91 drops/min                             1206. (c) The amount of Triamcinolone in 1%, 1 lb
                                                                  (454 gm) of ointment:
            We need to infuse 20cc + 50cc + 30cc + 1000cc =
            1100cc within 8 hours, therefore:                     =   454  = 4.54 grams Triamcinolone
                                                                     100
                1100    
            =            = 2.291    /                             If we add 5000 mg of Triamcinolone,
              8    60       

            I.V. set delivers 10 drops/cc, therefore:             = 4.54 gm + 5.0 gm


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