Page 37 - Fpgee Question And Answer 2024 Edition

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921.(a) Insulin Lispro (Humalog) is rDNA origin 924. (b) Cystic fibrotic patients secrete a large
derived from E.coli. It is human insulin analog. It has amount of viscous mucous in the bronchioles which
a rapid onset of action (about 10 to 15 minutes) and reduces the patients’ pulmonary function and
the shortest duration of action. It is indicated for increases the chances of inflammation.
the treatment of diabetes. Hypoglycemia,
tachycardia, confusion and lipoatrophy are reported Dornase α (Pulmozyme) is a recombinant human
side effects of the drug. deoxyribonuclease enzyme which metabolizes the
extracellular DNA found in mucous (due to a
922.(d) Meclizine (Antivert) is mainly indicated for degeneration of leukocytes). This helps reducing the
the treatment of vertigo. The recommended dose viscosity of mucous and aids restoring the normal
for the treatment of vertigo is 25 to 50 mg per day. pulmonary function in the patient.
Drowsiness, dizziness and anticholinergic side
effects are reported adverse effects of the drug. 925.(d) Zafirlukast (Accolate), Zileuton (Zyflo) and
Cromolyn Na (Intal) inhibit the slow release
923.(a) Methotrexate is a folic acid antagonist. substances of anaphylaxis (SRSA) that are
Methotrexate inhibits dihydrofolic acid reductase. responsible for bronchospasm.
Dihydrofolate must be reduced to tetrahydrofolates
by dihydrofolic acid reductase enzyme before they 926. (c) Flurazepam (Dalmane) is classified as
can be utilized as carriers of one-carbon groups in benzodiazepine. It has the longest duration of
the synthesis of purine nucleotides and action among the all benzodiazepines. It is indicated
thymidylate. for the short-term treatment of insomnia.
Depression, constipation, dizziness and drowsiness
Methotrexate may raise the serum concentration of are reported side effects of the drug.
uric acid and therefore should be carefully used in
patients suffering from gout. 927. (c) Effects of Warfarin (Coumadin) therapy can
be best monitored by PT (prothrombin time).
During Methotrexate therapy, patients should be Determination of anticoagulant plasma
periodically checked for whole blood counts, and concentration, bleeding time and clotting times are
hepatic and renal functions. not effective measures for monitoring Coumadin
therapy.

928.(c) Insulin increases the utilization and
oxidation of sugar in tissues. It stimulates the
transport of serum glucose to cells. It increases the
synthesis of glycogen in muscles and liver. It
stimulates the protein synthesis and growth. It also
reduces the breakdown of glycogen into glucose
and reduces serum glucose levels.

929. (b) Dryness of mouth, increase in thirst,
irregular heartbeat, muscle cramps and leg cramps
are signs of HCTZ-induced hypokalemia.

Rheumatrex is a brand name of Methotrexate 930.(d) Starvation may inhibit the secretion of
insulin to prevent hypoglycemia. The other all
available in dose pack. Methotrexate is generally choices may stimulate the secretion of insulin from
indicated for the treatment of leukemia, non- the pancreas.
Hodgkin’s disease, osteosarcoma, multiple
myeloma and arthritis.

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