Page 33 - Fpgee Question And Answer 2024 Edition

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reducing nicotine withdrawal symptoms. Seizure is G.I. hemorrhage are reported side effects of the
the principal side effect of the drug. It is drug. The recommended dose is 60 mg every 4
contraindicated to use in patients taking MAO hours, beginning within 96 hours after
inhibitors. subarachnoid hemorrhage, for 21 consecutive days.

Dosing should begin at 150 mg/day for the first 3 898.(b) Reye’s syndrome is associated with nausea
days, and then increases to 300 mg/day. The total and vomiting. Trimethobenzamide (Tigan) is
daily dose of Bupropion HCl (Zyban, Wellbutrin) classified as an antiemetic agent. It may mask
should not exceed more than 300 mg and should be symptoms and prolong the diagnosis of Reye’s
administered in two divided doses. syndrome in children.

894.(d) Verapamil (Calan) has a powerful AV node 899.(d) All. Bile acid sequestrants are used to
suppression property. Concurrent use with any reduce low density lipoprotein (LDL) cholesterol
Beta-blocker (e.g. Atenolol (Tenormin)) may result levels. After oral administration, they are not
in additive AV node suppression. absorbed but bind to bile acids (which contain
cholesterol) in the intestine and prevent their
Concurrent use of Calcium supplements like reabsorption into the body. The bound complex is
Calcium carbonate (Oscal) may elevate serum insoluble and is excreted in the faeces. Decrease in
calcium concentrations and reduce the therapeutic bile acid leads to an increase in hepatic synthesis of
effect of Verapamil. bile acids from cholesterol. Depletion of cholesterol
increases LDL receptor activity, therefore increases
Concurrent use of Digoxin (Lanoxin) with Verapamil removal of LDL cholesterol from the blood.
has been reported to increase the serum
concentration of Digoxin and its toxicity. Cholestyramine (Questran), Colestipol (Colestid)
and Colesevelam (Welchol) are bile acid binding
Disopyramide (Norpace) should not be resins indicated as an adjunctive therapy to diet and
administered within 48 hours of Verapamil exercise for the reduction of elevated lipid level.
administration, since both medications have high The usual recommended dose is three tablets twice
negative inotropic effects on the heart. a day with meals or 6 tablets once daily with a meal.
The most frequently reported side effects are
895.(b) Loteprednol (Alrex) is a federally approved constipation, dyspepsia and flatulence.
agent that is indicated for treatment of allergic
conjunctivitis. Prolonged use of steroids may 900.(c) Fentanyl (Duragesic) Transdermal system is
increase the intraocular pressure of the eyes. It available in 12**, 25, 50, 75 and 100 mcg/hr
should be used for a short-term only. strength. It should be changed every 3 days. The
initial recommended dose of drug is 25mcg/hour.
896. (d) The major side effect of all mentioned The dose can be gradually increased. It should not
drugs is pulmonary dysfunction. It would be be administered to children under age 12 or in
necessary to monitor pulmonary function in a patients under age 18 whose weight is less than 110
patient taking Bleomycin, Bromocriptine (Parlodel) lbs. Serious life threatening hypoventilation has
or Pentamidine (Pentam). been reported with a high dose of Fentanyl
(Duragesic) TDS.
897.(c) Nimodipine (Nimotop) is classified as a
calcium channel blocker. It is indicated for the **Nominal delivery rate should be 12.5mcg/hr.
treatment of cerebral spasm following
subarachnoid hemorrhage. It has a high lipid 901.(d) All. Furosemide (Lasix) is available in tablet,
solubility which facilitates its entry in the brain. oral solution and injection forms. It is classified as a
Hypotension, tachycardia, peripheral edema and loop diuretic. It is indicated for the treatment of

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