Page 32 - Fpgee Question And Answer 2024 Edition

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882.(d) Erythromycin is indicated for the treatment 887.(d) Tetracycline, sulfonamide, phenothiazine
of Legionnaires’ disease caused by Legionella and thiazide-diuretics may increase the sensitivity
pneumophilia. It is also indicated for the treatment of skin towards sunlight. Patients who are taking
of infections caused by mycoplasma pneumonia and these drugs for a prolonged period of time need to
campylobacter bacteria. avoid sunlight.

883.(d) Clofibrate (Atromid) is an 888.(b) Histamine is a compound derived from
antihyperlipidemic drug, not in the class of HMG- amino acid Histidine. It is normally associated with
COA reductase enzyme inhibitors. It is a fibric acid mast cells. It causes contraction of smooth muscles
derivative. It helps controlling elevated lipid levels and dilation of blood vessels. It increases the force
by: of contraction and rate of the heart. It also
stimulates gastric acid, and salivary and pancreatic
1. Inhibition of biosynthesis of cholesterol before secretions. It is released in large amounts after skin
mevalonate formation. damage.
2. Increasing the catabolism of VLDL.
889.(b) The normal therapeutic blood serum
It is recommended to take the drug with food to concentration of Phenytoin (Dilantin) is between 10
minimize G.I. upset. The usual dose of Clofibrate and 20mcg/ml. A 20 mcg/ml concentration
(Atromid) is 1.5 to 2.0 gm per day in 2 to 4 divided generally precipitates out nystagmus, 30mcg/ml
doses. may produce ataxia and 40mcg/ml produces
lethargy and dysarthria. It is indicated for the
884. (c) The mentioned symptoms indicate dystonic treatment of tonic-clonic seizure. The
reactions, which involve sudden spasms of neck, recommended dose is 300 to 400 mg per day in
face or trunk. Dystonic reactions can be managed divided dosing.
by anticholinergic agents like Diphenhydramine or
Benztropine. 890.(d) Lipoatrophy is the term describing the
localized loss of fat tissue. This may occur as a result
For the treatment of akathisia, Diazepam and of subcutaneous injections of insulin in the
anticholinergic agents are usually preferable. treatment of diabetes. It is recommended to rotate
the injection site frequently to avoid lipoatrophy.
For the treatment of drug-induced Parkinson’s, Diarrhea, abdominal pain, stomatitis and
anticholinergic drugs like Diphenhydramine or proteinuria are the adverse effects reported with
Benztropine have been found effective. use of gold compounds.

885.(d) Erythromycin Estolate (Ilosone) is the 891. (d) Cetirizine (Zyrtec), Fexofenadine (Allegra),
preferred erythromycin to use in children because Levocetirizine (Xyzal), Desloratadine (Clarinex) and
of its better absorption in the presence of food, and Loratadine (Claritin) are non-sedative
better G.I. tolerance compared to other antihistamines.
erythromycin salts. Erythromycin Estolate (Ilosone)
is highly hepatotoxic and responsible for causing 892.(d) The minimum weighable quantity for the
cholestatic hepatitis. class A prescription balance is 120mg.

886.(c) Bromocriptine (Parlodel) and Pergolide 893.(d) Bupropion HCl (Zyban, Wellbutrin) is a
Mesylate (Permax) are dopamine receptor agonists classified as antidepressant. It is indicated for the
indicated for the treatment of Parkinsonism. treatment of depression. It also helps reducing the
Tranylcypromine (Parnate) is an MAOA inhibitor urge to smoke. It is presumed to act on a
indicated for the treatment of depression. dopaminergic and noradrenergic pathway involved
in nicotine addiction and withdrawal. It also helps

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