Page 39 - RxExam's Naplex Theory Review Part-1

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Dose Special Notes

Spironolactone Short Test: Spironolactone (Aldactone) is administered at a daily
(Tablet) dosage of 400 mg for four days. If serum potassium increases during
Spironolactone (Aldactone) administration but drops when
Spironolactone (Aldactone) is discontinued, a presumptive diagnosis of
primary hyperaldosteronism should be considered.

4). Gynecomastia may develop in association with the use of
Spironolactone (Aldactone). The development of gynecomastia
appears to be related to both dosage level and duration of therapy and
it is normally reversible when Spironolactone (Aldactone) is discontinued.

5). Hyperkalemia, gynecomastia, irregular menses or amenorrhea are
commonly reported side effects of Spironolactone (Aldactone).

Eplerenone 25-50 mg PO QD 1). Eplerenone (Inspra), an aldosterone antagonist, blocks the binding
(Tablet) or BID, with or of aldosterone at mineralocorticoid receptors.
without food.
2). Eplerenone (Inspra) is indicated for the treatment of congestive
heart failure post-myocardial Infarction and hypertension.

3). Serum potassium should be measured before initiating Eplerenone
(Inspra) therapy, within the first week, and at one month after the start
of treatment or dose adjustment. Serum potassium should be assessed
periodically thereafter.

4). Hyperkalemia is the principal side effect of Eplerenone (Inspra).

Aliskiren 150-300 mg PO 1). Aliskiren (Tekturna) is a direct renin inhibitor, decreasing plasma
(Tablet) QD. renin activity (PRA) and inhibiting the conversion of angiotensinogen to
Angiotensin I.

2). Aliskiren (Tekturna) is indicated for the treatment of hypertension.

3). Patients should establish a routine pattern for taking Aliskiren
(Tekturna) with regard to meals. High fat meals decrease absorption
substantially.

4). Hyperkalemia, angioedema, cough, seizure and diarrhea are
reported side effects of Aliskiren (Tekturna).

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