Page 42 - RxExam's Naplex Theory Review Part-1

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Dose Special Notes

Diazoxide 2). Since it produces salt and water retentions, repeated injections of
(Injection) Diazoxide (Hyperstat) may cause edema and congestive heart failure.
(Capsule)
3). The use of Diazoxide (Hyperstat) I.V. for longer than 10 days is not
recommended.

4). It produces transient hyperglycemia (increase in blood glucose);
therefore blood glucose levels should be carefully monitored in
patients with diabetes.

5). It should only be administered via peripheral vein since the
alkalinity of solution may irritate the tissue if given via I.M. or S.C.
route.

Drug Interactions with Hydralazine, Minoxidil and Diazoxide

Estrogen Estrogen induced fluid retention may antagonize the
antihypertensive action of Hydralazine, Minoxidil and Diazoxide.

Indomethacin Salt and water retention produced by Indomethacin may antagonize
the action of antihypertensive action of Hydralazine, Minoxidil and
Diazoxide.

Sympathomimetic amine CNS stimulation produced by sympathomimetic amines may
antagonize the antihypertensive action of Hydralazine, Minoxidil
and Diazoxide.

Coumadin Diazoxide (Hyperstat) may displace Warfarin (Coumadin) from the
protein binding site and increase the bleeding tendency.

Thiazide diuretics They may increase the risk of hyperuricemia and hyperglycemia
when simultaneously used with Diazoxide (Hyperstat).

Sulfonylurea Hyperglycemia produced by Diazoxide (Hyperstat) may reduce the
effects of sulfonylurea.

Dose Special Notes

Treprostinil a). Remodulin: 1). Treprostinil (Remodulin, Tyvaso) is a pulmonary and systematic
(Injection) 0.625 to 1.25 vasodilator. It is indicated for the treatment of pulmonary arterial
(Inhalation) ng/kg/min hypertension.
subcutaneously
via continuous 2). Nausea, headache, diarrhea, hypotension and vasodilation are
infusion. commonly reported side effects of Treprostinil.

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