Page 44 - RxExam's Naplex Theory Review Part-1

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Dose Special Notes

Bosentan 3). Elevations in aminotransferases require close attention. Bosentan
(Tablet) (Tracleer) should generally be avoided in patients with elevated
aminotransferases (> 3 x ULN) at baseline because monitoring liver
injury may be more difficult. If liver aminotransferase elevations are
accompanied by clinical symptoms of liver injury (such as nausea,
vomiting, fever, abdominal pain, jaundice, or unusual lethargy or
fatigue) or increases in bilirubin ≥ 2 x ULN, treatment with Bosentan
(Tracleer) should be stopped.

Fenoldopam 0.01-1.6 mcg 1). Fenoldopam (Corlopam) is a Dopamine D 1 -like receptor agonist. It
(Injection) /kg/min via is indicated for the treatment of severe hypertension.
continuous I.V.
infusion 2). It should be administered by continuous intravenous infusion. A
bolus dose should not be used. Hypotension and rapid decreases of
blood pressure should be avoided. The initial dose should be titrated
upward or downward, no more frequently than every 15 minutes (and
less frequently as goal pressure is approached) to achieve the desired
therapeutic effect.

3). Hypotension and reflex tachycardia are reported side effects of
Fenoldopam (Corlopam).

Epoprostenol Initiate infusion 1). Epoprostenol (Flolan), a metabolite of arachidonic acid, is a
(Injection) at 2 ng/kg/min naturally occurring prostaglandin with potent vasodilatory activity and
and increase in inhibitory activity of platelet aggregation. It is indicated for the
increments of treatment of pulmonary arterial hypertension.
2ng/kg/min
every 15 2). Nausea, vomiting, hypotension, abdominal pain and headache are
minutes or reported side effects of Epoprostenol (Flolan).
longer until
dose-limiting 3). It is stable only when reconstituted with STERILE DILUENT for
pharmacologic Epoprostenol (Flolan). It must NOT be reconstituted or mixed with any
effects are other parenteral medications or solutions prior to or during
elicited. administration.

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