Page 37 - RxExam's Naplex Theory Review Part-1

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Dose Special Notes

Irbesartan 150-300 mg PO 1). Irbesartan (Avapro) is indicated for the treatment of hypertension
(Tablet) QD, with or and diabetic nephropathy with an elevated serum creatinine and
without food. proteinuria.

Candesartan 4-32 mg PO QD, 1). Candesartan (Atacand) is indicated for the treatment of
(Tablet) with or without hypertension and heart failure.
food.

Eprosartan 400-800 mg PO 1). Eprosartan (Teveten) is indicated for the treatment of hypertension.
(Tablet) QD, with or
without food.

Telmisartan 20-80 mg PO 1). Telmisartan (Micardis) is indicated for the treatment of hypertension
(Tablet) QD, with or and reduction of the risk of myocardial infarction, stroke, or death from
without food. cardiovascular causes.

Olmesartan 20-40 mg PO 1). Olmesartan (Benicar) is indicated for the treatment of hypertension.
(Tablet) QD, with or
without food.

Azilsartan 40-80 mg PO 1). Azilsartan (Edarbi) is indicated for the treatment of hypertension.
(Tablet) QD, with or
without food. 2). A pharmacist should not repackage Edarbi (Azilsartan medoxomil).
He should dispense and store Edarbi (Azilsartan medoxomil) in its
original container to protect Edarbi from light and moisture.

Common Notes: a). Angiotensin II receptor antagonists rarely cause the cough and angioedema that are
commonly reported with Ace-Inhibitors.

b). All angiotensin II receptor antagonists can be administered with or without food.

c). The use of Angiotensin II receptor antagonists in the second and third trimesters of pregnancy is not
recommended since they may produce injury and even death to the developing fetus.

Adverse Reactions:

1. Hyperkalemia
2. Headaches
3. Dysgeusia (loss of taste)
4. Fatigue, nausea and vomiting
5. When used in pregnancy during the second and third trimesters, Angiotensin II receptor antagonists
can cause injury and even death to the developing fetus.

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