Page 35 - RxExam's Naplex Theory Review Part-1

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Dose Special Notes

Captopril 3). Total urinary proteins greater than 1 g per day was seen in patients
(Tablet) receiving captopril. About 90 percent of affected patients had evidence
of prior renal disease or received relatively high doses of captopril (in
excess of 150 mg/day), or both. The nephritic syndrome occurred in
about one-fifth of proteinuric patients. In most cases, proteinuria
subsided or cleared within six months whether or not captopril was
continued.

4). The presence of food in the gastrointestinal tract reduces absorption
by about 30 to 40 percent; captopril therefore should be given one hour
before meals.

Benazepril 20-40 mg per 1). Benazepril (Lotensin) is indicated for the treatment of hypertension.
(Tablet) day given as a
single dose or in
two equally
divided doses.

Ramipril 2.5 - 20 mg per 1). Ramipril (Altace) is indicated for the treatment of hypertension,
(Tablet) day given as a heart failure post myocardial infarction, reduction in risk of myocardial
(Capsule) single dose or in infarction, stroke, and death from cardiovascular causes.
two equally
divided doses.

Fosinopril 20-40 mg PO 1). Fosinopril (Monopril) is indicated for the treatment of hypertension
(Tablet) QD. and heart failure.

2). In patients with impaired renal function, the total body clearance of
fosinoprilat (an active metabolite of Fosinopril) is approximately 50%
slower than in patients with normal renal function. Since hepatobiliary
elimination partially compensates for diminished renal elimination, the
total body clearance of fosinoprilat does not differ appreciably with any
degree of renal insufficiency including end-stage renal failure.
This relative constancy of body clearance of active fosinoprilat,
resulting from the dual route of elimination, permits use of the usual
dose in patients with any degree of renal impairment.

Trandolapril 2-4 mg PO QD. 1). Trandolapril (Mavik) is indicated for the treatment of hypertension,
(Tablet) heart failure post myocardial infarction and left-ventricular dysfunction
post myocardial infarction.

Moexipril 7.5-30 mg daily, 1). Moexipril (Univasc) is indicated for the treatment of hypertension.
(Tablet) given in one or
two divided doses 2). The bioavailability of Moexipril is significantly affected by the
One hour before presence of food. It should therefore be taken in a fasting state.
meals.

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