Page 28 - Fpgee Question And Answer 2024 Edition

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766. (c) Sodium polystyrene sulfonate is indicated the rapid onset of action and the shortest duration
for the removal of excess potassium ions from the of action. It is indicated for the treatment of
blood. It is a cation exchange resin indicated for the diabetes. Hypoglycemia, tachycardia, confusion,
treatment of hyperkalemia. The sodium ions of and lipoatrophy are reported side effects of the
resin are replaced with potassium ions. The drug.
therapeutic recommended dose is 15 grams four
times a day. 773.(b) Chlorpropamide (Diabinese) is classified as
an oral sulfonyl urea agent. It should be carefully
767. (b) Megestrol (Megace) is classified as a prescribed to geratic patients because of its
synthetic progestin. It is indicated for the treatment prolonged elimination half-life. The half-life of the
of advanced endometrial or breast cancer. It is also drug in normal patients is 24 to 60 hours. It is
used as an appetite stimulant agent for AIDS indicated for the treatment of type II diabetes
patients. The recommended dose for appetite mellitus. The recommended dose is 100mg to
stimulation is 400 mg twice a day. Cardiomyopathy, 250mg in a single or divided doses. Hypoglycemia,
hypertension and seizure are reported side effects tachycardia, diarrhea and water retention are
of the drug. reported side effects of the drug.

768. (b) Finasteride (Proscar) is indicated for the 774.(b) Acarbose (Precose) inhibits the breakdown
treatment of BPH. It is a specific inhibitor of 5 alfa of table sugar (sucrose) into glucose and fructose. It
azo-reductase enzyme, an enzyme responsible for is an inhibitor of alfa-glucosidase enzymes. It is
the conversion of testosterone into recommended to use dextrose instead of sucrose
dihydrotestosterone (DHT). Prostate cancer is highly for the treatment of hypoglycemia induced by
sensitive to the DHT concentration. It is Acarbose.
contraindicated in women who are or may become
pregnant. The recommended dose is 1 mg once a 775.(d) All the given choices are structurally related
day with or without meals. Impotence, decreased to thiazide diuretics, and should be carefully
libido, decrease volume of ejaculate are reported prescribed to the patient hypersensitivity to
side effects of the drug. thiazide diuretics.

769. (b) Peliosis hepatis, a condition in which the The patient hypersensitives to thiazide diuretic
liver and splenic tissues are replaced with blood- must avoid drugs containing sulpha groups in their
filled cysts, is a major adverse effect associated with structures such as sulphonamide groups of
anabolic steroids. It may lead to liver failure. antibiotics, oral sulfonylurea agents and celecoxib.

770. (b) Prostate cancer is known to be sensitive to 776.(b) Propylthiouracil (PTU) is classified as an
dihydrotestosterone. antithyroid agent. It inhibits the thyroid production
by preventing the incorporation of iodide into
771. (d) All. Etidronate disodium, Alendronate tyrosine and coupling of iodotyrosines.
sodium and Tiludronate sodium are indicated for
the treatment of Paget’s disease of bone. Estrogen It is indicated for the treatment of hyperthyroidism.
deficiency enhances the rate of bone resorption by It can be safely administered to pregnant women
osteoclasts. This will lead to the significant amount due to low fetal side effects. Agranulocytosis,
of loss of calcium from the bone. All the mentioned hemolytic anemia, skin rash, urticaria, hepatitis, and
choices inhibit the rate of bone resorption by nephritis are reported side effects of the drug. The
osteoclasts. recommended dose is 300 mg to 900 mg per day in
divided doses.
772. (c) Insulin Lispro (Humalog) is an rDNA origin
derived from E.coli. It is human insulin analog. It has

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