Page 27 - Fpgee Question And Answer 2024 Edition
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            757.(b)  The use of Procainamide (Procan) is highly   Name                              mEqs
            contraindicated  for  patients  suffering  from
            Myasthenia gravis. Its anticholinergic type of action   Potassium chloride              13.4
            decreases the acetylcholine released at the skeletal   Potassium bicarbonate            10.0
            muscle  motor  nerve  ending  and  may  worsen  the   Potassium citrate                 9.8
            Myasthenia  gravis.  It  is  classified  as  a  class  IA   Potassium gluconate         4.3
            antiarrhythmic  agent.  It  is  indicated  for  the   Potassium acetate                 10.2
            treatment  of  ventricular  arrhythmia.  Lupus
            erythematosus-like   syndrome,   agranulocytosis,
            hemolytic  anemia,  and  heart  block  are  also      763.(b and c)   Beta-carotene   and   rhodopsin,
            reported side effects of the drug.                    derivatives of vitamin A, help with visual adaptation
                                                                  to darkness. Physiological roles of other derivatives
            758.(b)  Procainamide  and  Hydralazine  may  cause   are as follows:
            SLE  (Systemic  Lupus  Erythematosus).  It  is  more
            likely  to  occur  in  patients  with  slow  acetylators.    Derivative   Its Function
            Arthritis, polyarthralgia, pleuritic pain, myalgia, skin
            lesions, fever, headache and fatigue are commonly     Retinol        Supports the reproductive cycle
            reported signs of SLE.
                                                                  Retinal        Functions in the visual cycle
            759.(c)  Disopyramide  (Norpace)  is  classified  as  a
            class IA antiarrhythmic agent. It is indicated for the   Retinoic acid   Promotes the growth,
            treatment    of    life-threatening   ventricular                    differentiation and maintenance
            arrhythmia.  It  has  a  powerful  negative  inotropic               of epithelial tissues
            (reduction  in  the  force  of  contraction  of  heart)
            effect  that  is  highly  contraindicated  for  patients
            suffering from congestive heart failure (CHF).        764. (b) Calcium gluconate has the lowest amount
                                                                  of  elementally  calcium  (4.6  mEqs).  Below  is  the
            Severe  myocardial  depression  with  hypotension,    summary  of  calcium  salts  and  their  calcium
            anticholinergic  side  effects  such  as  dry  mouth,   contents:
            urinary retention, constipation, and blurred vision,
            and symptoms of lupus erythematosus are reported      Name                             mEqs
            side effects of Disopyramide (Norpace).
                                                                  Calcium carbonate                20
            760.(d)  Malignant  hyperthermia,  CNS  toxicity  and   Calcium gluconate              4.6
            hepatic  failure  are  reported  side  effects  of    Calcium citrate                  12
            Lidocaine.                                            Calcium acetate                  12.6
                                                                  Calcium lactate                  9.2
            761.(c)  Class  IC  antiarrhythmic  agents  such  as   Calcium chloride                13.6
            Flecainide,  Encainide  and  Propafenone  should  be
            reserved for life-threatening arrhythmia because of
            their profound negative inotropic action.             765. (b) Quinidine is an alkaline drug in nature, and
                                                                  therefore  the  administration  of  urinary  alkalizer
            762.(a) Potassium  chloride  contains  the  highest   may  increase  the  reabsorption  of  quinidine  from
            mEq amount of potassium. Below is the summary of      the  renal  tubules.  Methotrexate,  Salicylate  and
            various potassium salts and their contents in mEqs.   Methenamine are acidic in nature, and alkalization
                                                                  of urine increase the excretion of these drugs.




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