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            Ketoacidosis:                                         752.(b)  Nitrostat  IV  >  Nitrostat  SL  >  Nitrolingual
                                                                  Spray > Nitro Dur TDS
            1. Presence of Acetone and glucose in urine
            2. Loss of appetite, abdominal pain                   Below  is  the  summary  of  various  nitroglycerine
            3. Acetone breath                                     products and their onset of actions.
            4. Rapid pulse
                                                                  Dosage forms            Onset of action (min)
            748. (c) Amiloride (Midamor) is a potassium sparing
                                                  +
                                               +
            diuretic  that  acts  by  inhibiting  the  Na   K   ATP  ase   I.V.           1 to 2
            activity. It is indicated for the treatment of edema   Sublingual             1 to 3
            associated  with  CHF,  hepatic  cirrhosis,  and      Translingual spray      2
            nephrotic  syndrome.  Hyperkalemia,  lethargy,        Transmucosal tab        1 to 2
            weakness,  electrolyte  loss  and  hypotension  are   Oral, sustain release   20 to 45
            reported   side   effects   of   the   drug.   The    Topical ointment        30 to 60
            recommended dose is 5 to 10 mg per day.               Transdermal             30 to 60

            749.  (c)  Digoxin  (Lanoxin)  is  classified  as  an
            inotropic agent, an agent that increases the force of   753.(c)  Dissolve one tablet under the tongue at the
            contraction  of  the  heart.  It  is  indicated  for  the   acute  onset  of  an  angina  attack;  repeat  every  5
            treatment  of  atrial  flutter,  atrial  fibrillation,  and   minutes  until  complete  relief  is  achieved.  Do  not
            CHF.  It  should  not  be  used  for  the  treatment  of   exceed  more  than  3  tablets  within  15-minute
            ventricular  fibrillation  since  it  may  induce     interval.
            automaticity  to  ventricles,  which  may  worsen  the
            ventricular  fibrillation.  The  recommended  dose  is   754.(c)  I.V.  administration  of  1/6  molar  sodium
            0.125mg to 0.25mg per day. The therapeutic serum      lactate  solution  causes  a  marked  decrease  in  the
            concentration of the drug shall be laid between 0.7   cardio toxic effects of Quinidine. Administration of
            and 1.4 ng/ml.                                        Diazepam  or  any  other  benzodiazepines  is
                                                                  contraindicated since profound CNS depression may
            Anorexia,   hypotension,   edema,    ventricular      occur during Quinidine toxicities.
            fibrillation and convulsion are reported side effects
            of the drug. The drug should be carefully prescribed   755.(c)  Ringing  in  the  ear,  headache,  nausea,
            with other agents that may induce hypokalemia.        vertigo  and  vision  disturbances  are  common  side
                                                                  effects reported with quinidine.
            750. (b) Myxedema is a thyroid disorder that occurs
            due  to  hyposecretion  of  the  thyroid  hormone.  It   756.(a) Quinidine  sulfate  contains  the  highest
            would normally reduce the rate of excretion of the    amount of anhydrous quinidine alkaloids. Below is
            Digoxin  (Lanoxin)  and  may  increase  the  serum    the summary of various salts of quinidine and their
            concentration and its toxicities in the blood. Digoxin   alkaloid contents:
            (Lanoxin)  dose  should  be  reduced  and  closely
            monitored in such patients.                           Name                              %

            751. (b)  Amrinone  has  vasodilation  as  well  as   Quinidine sulfate                 83%
            positive inotropic (increase the strength of muscular   Quinidine gluconate             62%
            contraction)  properties.  It  is  usually  known  as  an   Quinidine polygalacturonate   60%
            Inodilator  (Inotropic  +  Dilation).  It  is  indicated  for   Quinidine hydrochloride   0
            the treatment of heart failure. The prolonged use of
            Amrinone may cause severe thrombocytopenia.



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