Page 27 - RxExam's Naplex Theory Review Part-1

www.pharmacyexam.com Krisman

Dose Special Notes

Nifedipine 3). Adalat CC (nifedipine) tablets consist of an external coat and an internal
(Tablet) core. Both contain nifedipine, the coat as a slow release formulation
(Capsule) and the core as a fast release formulation.
(Tablet, ER)
4). Procardia XL (Nifedipine Extended Release (ER)) is similar in
appearance to a conventional tablet. It consists, however, of a
semipermeable membrane surrounding an osmotically active drug core.
The core itself is divided into two layers: an “active” layer containing
the drug and a “push” layer containing pharmacologically inert (but
osmotically active) components. As water from the gastrointestinal
tract enters the tablet, pressure increases in the osmotic layer and
“pushes” against the drug layer, releasing drug through the precision
laser-drilled tablet orifice in the active layer.

5). Angina patients controlled on Procardia (immediate release) may be
safely switched to Procardia XL at the nearest equivalent total daily dose
(e.g., 30 mg t.i.d. of Procardia capsules may be changed to 90 mg once
daily of Procardia XL.

6). Nifedipine is a preferred Calcium channel blocker to use with beta-
blockers since it has less effect on heart rate and A.V. node conduction
compared to other Calcium-channel blockers.

Diltiazem a). 30-90 mg PO 1). Diltiazem (Cardizem) is indicated for the treatment of angina due to
(Tablet) Q.I.D (IR). coronary artery spasm, chronic stable angina and hypertension.
(Capsule)
(Tablet, ER) b). 180-240 mg 2). The incidence of side effects increases as the dose increases with
(Capsule, ER) PO Q.D (ER) first-degree AV block, dizziness, and sinus bradycardia bearing the
(Injection) strongest relationship to dose.

3). Diltiazem (Cardizem) may produce severe A.V. node suppression and
therefore concurrent use with Beta-blockers may require careful
supervision.

Amlodipine 5-10 mg PO QD. 1). Amlodipine (Norvasc) is indicated for the treatment of vasospastic
(Tablet) angina, chronic stable angina, hypertension and angiographically
(Tablet, ODT) documented coronary artery disease (CAD).

2). Amlodipine (Norvasc) induced vasodilation has a gradual onset of
action; therefore chances of acute hypotension are very rare.

3). Amlodipine (Norvasc) produces less reflex sympathetic nervous
stimulation and reflex tachycardia compared to other Calcium-channel
blockers.

26