Page 24 - RxExam's Naplex Theory Review Part-1

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Dose Special Notes

Clonidine 3). The abrupt withdrawal of Clonidine therapy may increase the risk of
(Tablet) rebound hypertension. Patients should be advised not to discontinue
(Tablet, ER) therapy without consulting the physician. The sudden cessation of
(Extended therapy may produce hypertension, nervousness, agitation and headaches.
release oral
suspension), 4). When a patient is receiving both, a beta-blocker and Clonidine,
(TDS) discontinue the beta blocker several days before withdrawing Clonidine.
Discontinuing Clonidine before the beta blocker may result in severe
vasoconstriction due to unopposed alpha-adrenergic effects of
noradrenaline.

5). An extended-release formulation of Clonidine hydrochloride, known
as Kapvay, is approved for the treatment of attention deficit hyperactivity
disorder (ADHD) as monotherapy and as adjunctive therapy to stimulant
medications.

6). Orthostatic hypotension, dryness of mouth, drowsiness, sedation
and constipation are commonly reported side effects of Clonidine.

Guanfacine 1 mg to 3 mg 1). Guanfacine (Tenex, Intuniv) is an alpha-2 receptor AGONIST that
(Tablet) once a day at prevents the release of noradrenaline. It is indicated for the treatment
(Tablet, ER) bed time. of hypertension and ADHD.

2). Guanfacine (Tenex, Intuniv) should be taken at bedtime to prevent
somnolence, drowsiness and dizziness.

3). The frequency of rebound hypertension is less and more delayed in
nature compared to Clonidine. Sedation, drowsiness, dryness of mouth,
constipation and dizziness are reported side effects of Guanfacine.

4). An extended-release formulation of Guanfacine, known as Intuniv, is
approved for the treatment of attention deficit hyperactivity disorder
(ADHD) as monotherapy and as adjunctive therapy to stimulant medications.

Guanabenz 4 mg PO BID. 1). Guanabenz (Wytensin) is an alpha-2 receptor AGONIST that prevents
(Tablet) Do not exceed the release of noradrenaline. It is indicated for the treatment of
32 mg PO BID. hypertension.

2). Guanabenz (Wytensin) decreases the blood pressure in both
standing and supine positions and therefore the risk of postural
hypotension is the least compared to the other alpha-2 agonists.

3). A sudden cessation of therapy may produce severe hypertensive
crisis. Sedation, drowsiness, dryness of mouth, constipation and
dizziness are reported side effects of Guanabenz (Wytensin).

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