Page 9 - RxExam's Naplex Theory Book Part 2

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39. ERYTHROPOIESIS AND COLONY STIMULATING AGENTS

A). Erythropoiesis-Stimulating Agents (ESAs)

Epoetin alfa = Epogen, Procrit
Darbepoetin alfa = Aranesp
Epoetin beta methoxy = Mircera
propylene glycol

B). Colony Stimulating Factors (CSF)

Filgrastim = Neupogen
Pegfilgrastim = Neulasta
Sargramostim = Leukine

Dose Special Notes

Epoetin alfa 1. Anemia due to 1). Erythropoietin is a glycoprotein which stimulates red blood cell
(Injection) Chronic Kidney production. It is produced in the kidney and stimulates the division
Disease: and differentiation of committed erythroid progenitors in the bone
50 to 100 Units/kg marrow. Epoetin alfa (Epogen, Procrit), a 165 amino acid glycoprotein
3 times weekly IV manufactured by recombinant DNA technology, has the same
or SC. biological effects as endogenous erythropoietin.

2. Zidovudine 2). Epoetin alfa (Epogen, Procrit) is indicated for the anemia due to:
induced anemia:
100 Units/kg 3 a). Chronic Kidney Disease (CKD)
times weekly IV or b). Zidovudine in HIV-infected Patients
SC. c). Chemotherapy in Patients With Cancer
d). To reduce the need for allogeneic blood transfusions in anemic
3. Chemotherapy patients who are at high risk for perioperative blood loss from elective,
induced anemia: noncardiac, nonvascular surgery.
150 Units/kg
subcutaneously 3 3). In clinical studies, patients experienced greater risks for death,
times per week serious cardiovascular events, and stroke when administered
until completion erythropoiesis-stimulating agents (ESAs) to target hemoglobin levels of
of a chemotherapy 13 g/dL and above. Therefore, it is advisable to individualize dosing to
course. achieve and maintain hemoglobin levels within the range of 10 to 12
g/dL or precisely 11 g/dL.
4). Surgery Patients:
300 Units/kg per 4). An increased incidence of deep vein thrombosis, serious
day SC for 10 days cardiovascular events and strokes (especially in chronic renal failure
before surgery; on patients), pure red cell aplasia (PRCA), severe anemia, hypertension
the day of surgery and seizure are reported side effects of Epoetin alfa (Epogen, Procrit).
and 4 days after
surgery.

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