Page 13 - RxExam's Naplex Theory Book Part 2

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Dose Special Notes

Sargramostim 2). Sargramostim (Leukine) is indicated for:
(Injection)
a). Use following induction chemotherapy in older adult patients with
acute myelogenous leukemia (AML) to shorten time to neutrophil
recovery and to reduce the incidence of severe and life-threatening
infections and infections resulting in death.

b). The mobilization of hematopoietic progenitor cells into peripheral
blood for collection by leukapheresis. Mobilization allows for the
collection of increased numbers of progenitor cells capable of
engraftment as compared with collection without mobilization.

c). Acceleration of myeloid recovery in patients with non-Hodgkin's
lymphoma (NHL), acute lymphoblastic leukemia (ALL) and Hodgkin's
disease undergoing autologous bone marrow transplantation (BMT).

d). In patients who have undergone allogeneic or autologous bone
marrow transplantation (BMT) in whom engraftment is delayed or has
failed.

3). Headache, pericardial effusion, arthralgia, myalgia, fever,
abdominal pain, nausea, vomiting, arrhythmia, fainting, eosinophilia,
dizziness, hypotension, injection site reactions, pain (including
abdominal, back, chest, and joint pain), tachycardia, thrombosis, and
transient liver function abnormalities are reported with Sargramostim
(Leukine).

Terminology:

Neutropenia Neutropenia is a granulocyte disorder characterized by an abnormally
low number of neutrophils, the most important type of white blood
cell. Neutrophils usually make up 50-70% of circulating white blood
cells and serve as the primary defense against infections by destroying
bacteria in the blood. Hence, patients with neutropenia are more
susceptible to bacterial infections and, without prompt medical
attention, the condition may become life-threatening (neutropenic
sepsis).

Congenital Severe congenital neutropenia is a condition that causes affected
neutropenia individuals to be prone to recurrent infections. People with this
condition have a deficiency of neutrophils, a type of white blood cell
that plays a role in inflammation and in fighting infection. The
deficiency of neutrophils, called neutropenia, is apparent at birth or
soon afterward.

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