Page 7 - RxExam's Naplex Theory Book Part 2

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38. BENIGN PROSTATIC HYPERPLASIA

A). 5-Alpha-Reductase Inhibitors

Finasteride = Proscar
Dutasteride = Avodart

B). Specific Alpha-1 Blockers: (Please Refer Chapter 10 on page 64 of Part 1)

Prazosin = Minipress
Terazosin = Hytrin
Doxazosin = Cardura, Cardura Xl
Alfuzosin = Uroxatral
Silodosin = Rapaflo

C). Specific Alpha-1 Blockers in a Prostate Gland: (Please Refer Chapter 10 on page 64 of Part 1)

Tamsulosin = Flomax

D). Combination Agents:

Tamsulosin + Dutasteride = Jalyn

Definition: Benign Prostatic Hyperplasia is defined as an enlargement of the prostate gland which is often
associated with urination and bladder problems.

A). 5-Alpha-Reductase Inhibitors

Dose Special Notes

Finasteride 1. B.P.H. 1). Finasteride (Proscar) is a specific inhibitor of steroid Type II 5α-
(Tablet) 5 mg once a day reductase; an intracellular enzyme that converts the androgen
with or without testosterone into 5α-dihydrotestosterone (DHT). The development
food. and enlargement of the prostate gland is dependent on this potent
androgen, 5α-dihydrotestosterone (DHT).
2. Androgenetic
alopecia 2). It is indicated for the treatment of symptomatic benign prostatic
1 mg orally once hyperplasia (BPH) in men with an enlarged prostate to:
daily with or i). Improve symptoms
without food. ii). Reduce the risk of acute urinary retention (AUR)
iii). Reduce the risk of the need for surgery including transurethral
resection of the prostate (TURP) and prostatectomy.

3). In combination with the alpha-blocker Doxazosin, It is indicated to
reduce the risk of symptomatic progression of BPH.

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