Page 14 - RxExam's Naplex Theory Review Part-1

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Dose Special Notes

Flecainide c). For the prevention of documented ventricular arrhythmias, such as
(Tablet) sustained ventricular tachycardia (sustained VT), that in the judgment
of the physician are life-threatening.

2). Flecainide (Tambocor) should be carefully used in patients with
heart failure (CHF), since it has powerful negative inotropic action.
Dizziness, visual disturbances, dyspnea, headache and heart failure are
reported side effects of Flecainide (Tambocor).

Propafenone 150 mg to 300 1). In patients without structural heart disease, Propafenone (Rythmol)
(Tablet) mg PO every 8 is indicated to prolong the time to recurrence of:
(Capsule, ER) hours.
a). Paroxysmal supraventricular tachycardia (PSVT) associated with
disabling symptoms.
b). Paroxysmal atrial fibrillation/flutter (PAF) associated with disabling
symptoms.
c). For the prevention of documented ventricular arrhythmias, such as
sustained ventricular tachycardia (sustained VT), that in the judgment
of the physician are life-threatening.

2). Type IC antiarrhythmic agents like Flecainide (Tambocor) and
Propafenone (Rythmol) should be reserved for patients with life-
threatening arrhythmia.

3). Unusual taste, nausea, vomiting, dizziness and cardiac failure are
reported side effects of Propafenone.

Moricizine 200 mg to 300 mg 1. Moricizine (Ethmozine) is indicated for the prevention of documented
(Tablet) PO every 8 hours. ventricular arrhythmias, such as sustained ventricular tachycardia
(sustained VT), that in the judgment of the physician are life-threatening.

2. Hypokalemia, hyperkalemia or hypomagnesemia may alter the effects
of Class I antiarrhythmic drugs. Electrolyte imbalances should be
corrected before administering Moricizine (Ethmozine).

3. Proarrhythmia, heart failure, nausea, ECG abnormalities, dizziness
and anxiety are reported side effects of Moricizine.
Drug Interactions with Tambocor:
Amiodarone When amiodarone is added to flecainide therapy, plasma flecainide
levels may increase two-fold or more in some patients, if flecainide
dosage is not reduced.

Disopyramide or Neither disopyramide nor verapamil should be administered
Verapamil concurrently with flecainide because both drugs have negative
inotropic property.

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