Page 42 - Naplex Q&A 2025 Version

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Hypokalemia, weakness, lethargy, dizziness, is available in single-dose vials as a ready-to-use (7.5
hyperglycemia, and orthostatic hypotension are mg/mL) aqueous solution for intramuscular use
reported side effects of the drug. only.

29.(c) Xolegel contains the antifungal agent It should be carefully prescribed with enzyme
Ketoconazole 2% in a topical anhydrous gel vehicle inhibitors. The dosage of Abilify should be reduced
for topical administration. It is indicated for the to half when prescribed with Paxil (Paroxetine),
topical treatment of seborrheic dermatitis in Prozac (Fluoxetine), Quinidine and Nizoral
immuno competent adults and children 12 years of (Ketoconazole). Tegretol (Carbamazepine) induces
age and older. The gel should be applied once daily the metabolism of Abilify and reduces the
to the affected area for 2 weeks. Xolegel is for pharmacological activity of the drug. The dosage of
topical use only, and not for oral, ophthalmic, or Abilify should be doubled when simultaneously
intra vaginal use. administered with Tegretol (Carbamazepine).

30.(d) Geodon (Ziprasidone) is an antipsychotic 33. (a) Lovenox (Enoxaparin sodium) is classified as
agent. It is available as capsules for oral a low molecular weight heparin. It is indicated for
administration and as an injection for intramuscular the treatment of embolism after knee replacement
use only. surgery. The recommended therapeutic dose of the
drug is 30 mg via subcutaneously every 12 hours.
Each capsule for oral administration contains 20mg,
40mg, 60mg or 80mg Ziprasidone. Each mL of Bleeding, hemorrhage, hematoma at injection site,
Ziprasidone mesylate for injection (when thrombocytopenia and priapism are reported side
reconstituted) contains 20 mg of Ziprasidone. effects of the drug. It should be carefully prescribed
to patients with heparin hypersensitivity.
It is indicated for the treatment of schizophrenia, as
monotherapy for the acute treatment of bipolar 34.(e) Category X indicates the highest risk to the
manic or mixed episodes, and as an adjunct to developing fetus. The following is the summary of
lithium or valproate for the maintenance treatment the highest risk category to the lowest risk category
of bipolar disorder. It has the tendency to prolong to developing fetus. X>D>C>B>A where (A) includes
the QT/QTc interval. This may lead to torsade de the list of drugs that have been shown as having the
pointes arrhythmia, polymorphic ventricular least risk to a developing fetus.
tachycardia and sudden death. It should be carefully
prescribed to patients suffering from any type of 35.(e) Cozaar (Losartan), Diovan (Valsartan),
heart disease. Avapro (Irbesartan), Benicar (Olmesartan) and
Micardis (Telmisartan) are classified as Angiotensin
31.(b) The administration of Toradol (Ketorolac II receptor antagonists. They rarely produce cough
tromethamine) by oral route provides more and angioedema, which is a common problem with
bioavailability compared to the parenteral route. Angiotensin Converting Enzyme Inhibitors. They are
indicated for the treatment of hypertension.
32.(c) Abilify (Aripiprazole) is a psychotropic drug
that is available as tablets, orally disintegrating The severe hypotension in volume depleted
tablets or discmelt, an oral solution, and a solution patients and hyperkalemia are principal side effects
for intramuscular injection. Abilify tablets are of these drugs. They should be carefully prescribed
available in 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, and during the second and third trimesters of
30 mg strengths. Its orally disintegrating tablets are pregnancy.
available in 10 mg and 15 mg strengths. Abilify oral
solution is a clear, colorless to light yellow solution
available in a concentration of 1 mg/ml. Its injection

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