Page 41 - Naplex Q&A 2025 Version

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system is available in 0.1, 0.2 and 0.3 mg of TTS monthly (no sooner than 26 days after the previous
strength. The Catapres TTS should be changed once injection).
a week.
After the first Abilify Maintena injection, continue
Tachycardia, anorexia, orthostatic hypotension and treatment with oral aripiprazole (10 mg to 20 mg)
impotence are reported side effects of the drug. or other oral antipsychotic for 14 consecutive days
to maintain therapeutic antipsychotic
26.(b) The stimulation of alpha-2 receptor prevents concentrations during initiation of therapy.
the release of noradrenaline. Clonidine is an alpha-2
receptor agonist or stimulant. By stimulation of this If there are adverse reactions with the 400 mg
receptor, it helps controlling patients’ hypertension. dosage, consider reducing the dosage to 300 mg
once monthly.
27.(b, c, and d) Abilify (Aripiprazole) is classified as
an antipsychotic agent. Abilify oral tablets, orally- Aristada is available as an aqueous extended-
disintegrating tablets, and oral solution are release suspension for intramuscular injection in
indicated for the treatment of: the following strengths of Aripiprazole Lauroxil (and
deliverable volumes from a single-use pre-filled
1. Schizophrenia. syringe): 441 mg (1.6 mL), 662 mg (2.4 mL) and 882
2. Acute Treatment of Manic and Mixed Episode mg (3.2 mL).
associated with Bipolar I Disorder.
3. Adjunctive Treatment of Major Depressive Depending on individual patient's needs, treatment
Disorder. with Aristada can be initiated at a dose of 300 mg,
4. Irritability Associated with Autistic Disorder. 450 mg and 600 mg of Aripiprazole. Treatment may
5. Treatment of Tourette's Disorder. also be initiated with the 600 mg dose every 6
weeks.
Abilify Injection is indicated for the treatment of:
NMS, tardive dyskinesia, extrapyramidal symptoms
1. Agitation associated with schizophrenia or bipolar and agitation are reported side effects of Abilify. It
mania. is available as a tablet for an oral administration.

The recommended starting and target oral dose for 28.(e) Lasix (Furosemide) is classified as a loop
Abilify is 10 or 15 mg/day administered on a once-a- diuretic. This class of drugs has a distinct action on
day schedule without regard to meals. Dosage the renal tubules function and so called high ceiling
increases should generally not be made before 2 diuretics. They inhibit sodium and chloride
weeks, the time needed to achieve steady-state. reabsorption in the ascending limb of loop of Henle,
hence they are known as loop diuretics.
Abilify Maintena (Aripiprazole) is an extended-
release injectable suspension available in 400-mg or Lasix (Furosemide) is indicated for the treatment of
300-mg strength pre-filled dual chamber syringes edema associated with heart failure (CHF),
and 400-mg or 300-mg strength vials. nephrotic syndrome and hepatic cirrhosis. The
recommended therapeutic dose of the drug is 20 to
Abilify Maintena is only to be administered by 80 mg per day.
intramuscular injection by a healthcare
professional. For patients who have never taken An I.V. administration of Furosemide may reduce
Aripiprazole, establish tolerability with oral the pulmonary vascular congestion and pulmonary
aripiprazole prior to initiating treatment with Abilify venous pressure by systematic venous dilation.
Maintena. The recommended starting and Lasix oral solution should be protected from light. It
maintenance dose of Abilify Maintena is 400 mg is available as tablet, oral solution and injection.

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