Page 38 - Naplex Q&A 2025 Version

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exchange site in the distal convoluted renal tubule. an antifungal agent. It is indicated for the treatment
Aldactone causes increased amounts of sodium and of invasive fungal infections caused by invasive
water to be excreted, while potassium is retained. aspergillosis.
Aldactone acts both as a diuretic and as an
antihypertensive drug by this mechanism. It may be The recommended daily dosage for adults and
given alone or with other diuretic agents which act children is 5 mg/kg given as a single infusion.
more proximally in the renal tubule. Abelcet should be administered by intravenous
infusion at a rate of 2.5 mg/kg/h. If the infusion
For the treatment of edema in adults, an initial daily time exceeds 2 hours, mix the contents by shaking
dosage of 100 mg of Aldactone administered in the infusion bag every 2 hours. Patients should be
either single or divided doses is recommended, but pretreated with antipyretics, antihistamines,
may range from 25 to 200 mg daily. antiemetics and with Meperidine to reduce the
signs and symptoms of shaking chills and fever.
For the treatment of essential hypertension, an
initial daily dosage of 50 to 100 mg of Aldactone Abdominal pain, anorexia, anxiety, hypokalemia,
administered in either single or divided doses is anemia, nephrotoxicity and diarrhea are reported
recommended. Aldactone in a dosage ranging from side effects of the drug.
25 mg to 100 mg daily is useful in treating a
diuretic-induced hypokalemia, when oral potassium 11.(a) Gardasil is a vaccine indicated in girls and
supplements or other potassium-sparing regimens women 9 through 26 years of age for the
are considered inappropriate. prevention of the following diseases caused by
Human Papillomavirus (HPV) types included in the
Gynecomastia (excessive development of the male vaccine:
breasts), fever, urticaria and hyperkalemia are
reported side effects of the drug. 1. Cervical, vulvar, and vaginal cancer caused by
HPV types 16 and 18.
All other choices such as Zaroxolyn (Metolazone),
Hygroton (Chlorthalidone), Diuril (HCTZ) and 2. Genital warts (condyloma acuminata) caused by
HydroDiuril (HCTZ) are thiazide diuretics that may HPV types 6 and 11.
exacerbate patient’s hypokalemia.
It is also indicated in boys and men 9 through 26
9.(d) Dulcolax (Bisacodyl) is a stimulant laxative. Its years of age for the prevention of genital warts
onset of action is about 8 to 10 hours when taken (condyloma acuminata) caused by HPV types 6 and
orally. The rectal dosage form (suppository) acts 11.
more rapidly than an oral dosage form.
12. (e) Erythromycin and other antibiotics may
It should never be given with milk, dairy products or increase the absorption of Digoxin by altering the
antacids since its enteric coated form may dissolve normal GI flora in the stomach which inactivates
at an alkaline pH and cause a severe G.I. irritation. It Digoxin prior to its absorption.
is indicated for the treatment of chronic
constipation. The recommended dose is 5 to 10 mg When used simultaneously with Quinidine, the
by mouth at bed time. serum concentration of Digoxin may normally raise
which results in increased toxic effects of Digoxin.
10.(c) The active ingredient found in Abelcet is Colestid (Colestipol) and Questran (Cholestyramine)
Amphotericin B. It is also available under the may reduce the absorption of Digoxin by binding to
following trade names: Amphotec (a powder for the acidic moiety of Digoxin.
injection), and AmBisome (a liposomal form). It
should be given parenterally via an I.V. infusion. It is

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