Page 8 - RxExam's Naplex Theory Review Part-1

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Dose Special Notes

Dobutamine 3). Because of the risk of severe physical incompatibilities, it should
(Injection) not be mixed with alkaline solutions such as sodium bicarbonate.

4). Hypotension, tachycardia, ventricular ectopic activity, and
increased blood pressure are reported side effects of Dobutamine.

Milrinone Loading dose: 1). Milrinone (Primacor) inhibits cAMP phosphodiesterase enzyme in
(Injection) 50mcg/kg, given cardiac and smooth muscles.
slowly over 10
minutes. 2). It is indicated for the short-term treatment of patients with acute
decompensated heart failure.
Maintenance
dose: 3). Ventricular arrhythmia, ventricular tachycardia, hypotension, chest
0.77mg/kg/24 pain, thrombocytopenia and tremor are reported side effects of
hours. Milrinone (Primacor).

Treatment of overdose of Digoxin

Condition Recommendation

Hypokalemia Potassium supplements
Arrhythmia Lidocaine or Phenytoin
Toxication Digoxin Immune Fab (38 mg of Digoxin Immune Fab neutralizes 0.5mg
of Digoxin), cholestyramine and activated charcoal

Name of Drug Drug Interactions with Lanoxin

Diuretics Hypokalemia induced by diuretics increases the Digoxin’s toxicity.

Antacids, Inhibit the absorption of Digoxin.
Cholestyramine,
Colestipol

Quinidine, May elevate the serum concentration and toxicities of Digoxin.
Quinine,
Amiodarone

Thyroid May decrease therapeutic effects of Digoxin by enhancing its
supplements metabolism.

Diltiazem, Concurrent use with Digoxin may result in excessive bradycardia
Verapamil because of an additive AV node suppression caused by calcium
channel blockers.

Indomethacin Decreases the renal clearance of Digoxin and increases its toxicities.

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