Page 48 - Naplex Q&A 2025 Version

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response. Ordinarily, optimal clinical response is doses. It is available in tablet, injection and oral
achieved at daily doses below 60 mg/kg/day. The solution.
extended release tablet form is also used for the
treatment of mania (associated with bipolar Headache, somnolence, fatigue, nausea, vomiting
disorder) and migraine. It is available in tablet, and abdominal discomfort are reported side effects
extended release tablet, sprinkle capsule and syrup of the drug.
forms.
55.(d) Travatan Z (Travoprost) is a new formulation
The recommended initial dose for the treatment of of Travatan solution in which benzalkonium chloride
mania is 750 mg daily in divided doses. The dose is replaced with SofZia, a robust ionic buffered
should be increased as rapidly as possible to preservative system that is gentle to the ocular
achieve the lowest therapeutic dose which surface.
produces the desired clinical effect or the desired
range of plasma concentrations. For the treatment Travoprost is a synthetic prostaglandin F analogue.
of migraine, the recommended starting dose is 250 It is indicated for the reduction of elevated
mg twice daily. Some patients may benefit from intraocular pressure in patients with open-angle
doses up to 1000 mg/day. glaucoma or ocular hypertension, who are
intolerant of or insufficiently responsive to other
The major adverse effects of Valproic acid are intraocular pressure lowering medications.
hypoprothrombinemia, pancreatitis, teratogenicity
and hepatotoxicity. The recommended dosage is one drop in the
affected eye(s) once daily in the evening. It should
52.(c) Depakote (Valproate sodium) is a highly not be administered more than once daily since it
hepatotoxic drug responsible for the elevation of has been shown that more frequent administration
liver enzymes and producing hepatotoxicity. of prostaglandin analogs may decrease the
intraocular pressure lowering effect.
53.(e) Chris is allergic to belladonna alkaloids and
phenobarbital. The active ingredients found in 56.(e) Tagamet (Cimetidine) has a CP450 inhibition
Butibel are (belladonna + butalbital). Donnatal property that inhibits the metabolism of a number
Extentab contains (atropine + hyoscyamine + of drugs. It increases the toxicities of Theophylline
scopolamine + phenobarbital) whereas Transderm and Ketoconazole.
Scop contains Scopolamine as an active ingredient.
Atropine, hyoscyamine and scopolamine are Also, concurrent use of antacids and H2 receptor
derivatives of belladonna alkaloids. All these drugs antagonists may not be recommended since the
should be avoided by Chris. absorption of H2 receptor antagonists may be
impaired by antacids. Patients should be advised
54. (e) Tagamet (Cimetidine) is classified as a not to take any antacids within one-half to 1 hour of
Histamine H2 receptor antagonist. It is indicated for taking any H2 receptor antagonist.
the treatment of G.I. and duodenal ulcers,
gastroesophageal reflex disease, erosive esophagitis 57.(b) Anaprox (Naproxen sodium) is available as an
heartburn and the treatment of pathological OTC counter pain reliever medication. Anaprox DS is
hypersecretory conditions (i.e., Zollinger-Ellison 550 mg of Naproxen sodium; and requires a
Syndrome, systemic mastocytosis, multiple prescription for purchase.
endocrine adenomas).
58.(c) NSAIDs are used for pain, dysmenorrhea and
The recommended therapeutic dose of the drug is bursitis. The G.I. ulceration and bleeding have been
400 to 1600 mg per day in two to four divided reported with the use of NSAIDs. Any OTC NSAID

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