Page 25 - FPGEE Medicinal and Organic Chemistry Q&A Book

Krisman

NH NH 3 NH NH
3 + O + 3 3
Na Na
Pt + 2 - O S O - Pt

Cl Cl O S O - S O -
2 NaCl 2 3 2 3
+
+
Cisplatin Sodium thiosulfate Na Na
water soluble

Fig: 11.14

CH 2 CH 2 S CH 2 CH 2
CH CH 2 + CH 2 CH 2 -
- CHO SO 3
CHO SO 3 SH

(Acrolein) (Mesna) water soluble non-toxic product

Fig: 11.15

Anthracyclines

NADPH reductase

-
O O :

super oxide radical anion

+ superoxide dismutase
H 2
Cu +2

Catalase Fe +2 -
H O + O H O .OH + OH + Fe +3
2 2
2 2
Cytotoxic
hydroxy
free radical
Fig: 11.16

(formation of cytotoxic free radicals by anthracyclenes)

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