Page 18 - FPGEE Medicinal and Organic Chemistry Q&A Book

Krisman

256. 4,4'-diaminodiphenylsulfone is the a. I only
chemical name for: b. I and II only
c. II and III only
a. Sulfamethoxazole d. All
b. Rifampin
c. Dapsone 260. Cisplatin-induced nephrotoxicity can be
d. Thalidomide minimized by administering:
NH 3 Cl
257. The principal side effect of the com-
pound shown below is: Pt

NH Cl NH Cl
3 3
Pt Cisplatin

NH Cl a. Sodium bicarbonate
3
b. Mesna
a. Cardiac toxicity c. Sodium thiosulfate
b. Severe nausea and vomiting d. Aluminum phosphate
c. Respiratory failure
d. Severe rash
261. What is the water-soluble non-toxic
258. Cis-diamminedichloridoplatinum shall product of the following reaction?
be carefully prescribed with:
CH CH + Mesna
2 ?
I. Cyclophosphamide CHO
II. Ifosfamide (Acrolein)
III. Streptomycin
a. CH CH CHO
3 2
a. I only b. CH CH SHCHO
3 2
b. I and II only c. CHOCH CH SCH CH SO -
2 2 2 2 3
c. II and III only d. CH CH CH SHCHCOO -
3 2 2
d. All
262. Triethylenephosphoramide is an active
259. Which of the following statements are metabolite of:
TRUE about Cisplatin-induced nephrotoxicity?
a. Procarbazine
I. Patients should be hydrated with b. Carmustine
chloride- containing solution prior to therapy. c. Thiotepa
d. Ifosfamide
II. Saline or mannitol diuretics should be
used continuously throughout the therapy.

III. Prolonged dialysis shall be used to
minimize cisplatin induced nephrotoxicity.

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