Page 8 - Referance Guide For Pharmaceutical Calculations (Naplex, Fpgee and Ptce)

Where, C = total buffer concentration,
H3O = hydrogen ion concentration,
+
Ka = equilibrium constant for the reaction.

 max = 0.576xC (Maximum Buffer Capacity Equation)

where C = total buffer concentration,
where βmax= maximum buffer capacity.

Half Life and Kinetic Calculation

2.303 where Co = initial concentration of drug,
=

where C = concentration of drug at time ‘t’.

t 1/2 = 0.693/K where t1/2 = half-life of drug,
where K = rate constant.

Body Clearance Based Calculation

Vd = M/Cp where Vd = volume of distribution,
where M = amount of drug in body
where Cp = plasma concentration of drug

Ri = Css x Vd x K where Ri = rate of infusion
where Css = steady state plasma concentration
where Vd = volume of distribution
where K = drug elimination constant

Ld = Css x Vd where Ld = loading dose of drug
where Css = steady state plasma concentration
where Vd = volume of distribution

weight(kg)x (140−age)
CrCl =
72 x serum creatinine (mg/dl)

CrCl (Female) = 0.85 x male (CrCl)

Temperature Conversion

o
(℉−32) 5 where C = temperature in degree Celsius
℃ = = 0.55 x (℉ − 32)
9 where F = temperature in degree Fahrenheit
o

o
9 where C = temperature in degree Celsius
℉ = ( ℃) + 32 = 1.8℃ + 32
5 where F = temperature in degree Fahrenheit
o

*MCT = Medium Chain Triglycerides
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