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Which of the following is/are 5-alpha-reductase inhibitors?

I. Propecia
II. Avodart
III. Jalyn

a. I only
b. III only
c. I and II only
d. II and III only
e. All

Answer: (e) All. 5-Alpha-reductase inhibitors block the action of 5-alpha-reductase, the enzyme that converts testosterone into dihydrotestosterone, which has greater affinity for androgen receptors. The activity of 5-alpha-reductase inhibitors results in increased levels of testosterone and decreased levels of dihydrotestosterone.

The development and enlargement of the prostate gland is dependent on the potent androgen, 5-alpha-dihydrotestosterone (DHT). By reducing the levels of dihydrotestosterone, 5-Alpha-Reductase inhibitors prevent the development and enlargement of the prostate gland.

5-Alpha-reductase inhibitors are used to treat baldness, prostate hyperplasia and prostate cancer.
Below is the list of 5-Alpha-Reductase inhibitors:

1. Finasteride = Proscar, Propecia
2. Dutasteride = Avodart
3. Dutasteride + Tamsulosin = Jalyn

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