Page 66 - Naplex Q&A 2025 Version

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Following the second dose, monthly maintenance 144.(b) The principal adverse effect of Questran
doses can be administered in either the deltoid or (Cholestyramine) is constipation. It can be
gluteal muscle. It is intended for intramuscular use prevented by taking the drug with plenty of water,
only. and using a stool softener or any laxative product.
Colace (Docusate Na) is a stool softener. It helps
Orthostatic hypotension, leukopenia, relieving constipation induced by Questran.
agranulocytosis, weight gain, suicide,
extrapyramidal symptoms, tardive dyskinesia and 145.(e) Increased in blood glucose and uric acid
dystonia are reported side effects of the drug. concentration, and elevation of hepatic
transaminase enzymes are major complications of
139.(c) Human insulin is the least immunogenic in Niacin therapy. Therefore, its use required great
nature compared to endogenous insulin. caution in patients suffering from diabetes, gout or
an impaired liver function.
140.(c) From looking at the chart, it is clear that
Mehta’s noon and bed time blood glucose 146.(a) Paliperidone, the active ingredient in Invega
concentrations are outside the range of required extended-release tablets, is an anti-psychotic agent.
normal blood glucose level (80 to 120 mg/dl). These It is indicated for the acute and maintenance
can be prevented by increasing the morning and treatment of schizophrenia. Invega tablet uses
evening NPH insulin doses. osmotic pressure or OROS system to deliver
Paliperidone at a controlled rate.
141.(e) Age, sex and family history are risk factors
associated with the development of diabetes. The delivery system, which resembles a capsule-
shaped tablet in appearance, consists of an
142. (d) Acova (Argatroban) is classified as a osmotically active trilayer core surrounded by a sub
synthetic direct thrombin inhibitor. It is indicated as coat and semipermeable membrane. The trilayer
an anticoagulant for prophylaxis or treatment of core is composed of two drug layers containing the
thrombosis in heparin-induced thrombocytopenia. drug and excipients, and a push layer containing
osmotically active components.
The recommended dose of Acova in adults is 2
mcg/kg/min administered as a continuous infusion. There are two precision laser-drilled orifices on the
drug-layer dome of the tablet. Each tablet-strength
Bleeding is the principal side effect of the drug. has different colored water-dispersible overcoat
Abdominal pain, bradycardia, headache, chest pain and print markings. In an aqueous environment,
and vomiting are also reported with the drug. such as the gastrointestinal tract, the water-
Therapy should be monitored by regularly obtaining dispersible color overcoat erodes quickly. Water
aPTT and INR. then enters the tablet through the semipermeable
membrane that controls the rate at which water
143.(e) Niacin is classified as an anti-hyperlipidemic enters the tablet core, which, in turn, determines
agent. It is indicated for the treatment of elevated the rate of drug delivery. The hydrophilic polymers
serum triglycerides levels. The recommended dose of the core hydrate and swell, creating a gel
is 1 to 2 grams in two to three divided doses. containing Paliperidone that is then pushed out
through the tablet orifices.
Liver toxicity, flushing and rhabdomyolysis are
reported side effects of the drug. Flushing can be The recommended dose of Invega (Paliperidone)
minimized by taking the drug with food, initiating extended-release tablets for the treatment of
therapy with a low dose, and pretreating patients schizophrenia is 6 mg once daily, administered in
with Aspirin or NSAIDs. the morning. Dose increases above 6 mg/day should
be made only after clinical reassessment and

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