Page 61 - Naplex Q&A 2025 Version

www.pharmacyexam.com

may be required to assess whether a beneficial reported with the use of Tyzeka (Telbivudine) alone
response has been achieved. The first dose syncope, or in combination with antiretrovirals.
tachycardia and weight gain are reported side
effects of the drug. Severe acute exacerbations of hepatitis B have been
reported in patients who have discontinued anti-
114.(e) Prozac (Fluoxetine HCL) is classified as an hepatitis B therapy, including Tyzeka. Hepatic
SSRI (Selective Serotonin Reuptake Inhibitor). It is function should be monitored closely with both
available in oral solution, tablet, weekly capsule and clinical and laboratory follow-up for at least several
pulvules form. months in patients who discontinue anti-hepatitis B
therapy. If appropriate, resumption of anti-hepatitis
Each Pulvule contains 10mg, 20mg or 40mg B therapy may be warranted.
Fluoxetine. Prozac Weekly capsules, a delayed-
release formulation, contain enteric-coated pellets 117.(c) Effects of Coumadin therapy can be best
of Fluoxetine hydrochloride equivalent to 90 mg. monitored by regularly checking PT (Prothrombin
time). Determination of anticoagulant plasma
It is indicated for the treatment of: concentration, bleeding time and clotting times are
not effective measures for monitoring Coumadin
1. Acute and maintenance treatment of Major therapy. Heparin therapy should be monitored by
Depressive Disorder. regularly checking an activated partial
2. Acute and maintenance treatment of obsessions thromboplastin time (aPTT).
and compulsions in patients with Obsessive
Compulsive Disorder (OCD). 118.(e) It is advisable to do the PT determination
3. Acute and maintenance treatment of binge- prior to initiating the therapy and 24 hours after
eating and vomiting behaviors in patients with initiating the therapy. It should be done twice a
moderate to severe Bulimia Nervosa. week for one month once the maintenance dose
4. Acute treatment of Panic Disorder, with or has been established. After a one month period, it
without agoraphobia. should be done weekly for the rest of the
5. In combination with Zyprexa (Olanzapine) under treatment.
the trade name of Symbyax, it is indicated for acute
treatment of depressive episodes associated with 119.(c) PT and INR are two most important
Bipolar I Disorder and treatment resistant measurements for monitoring Coumadin therapy.
depression. Prothrombin time (PT) is often indicated by values
6. Under the brand name of Sarafem, it is indicated in seconds compared to the control values of PT in
for the treatment of premenstrual dysphoric seconds. But since tissue thromboplastin which is
disorder (PMDD). generally used for determination of PT is less
sensitive and identical, the World Health
The recommended dose is 20 mg to 60 mg per day. Organization introduced a standardized system for
It should be given in the morning to avoid insomnia. reporting PT values. In this system they use an INR
Anxiety, nervousness, insomnia, irritability, mania, (International Normalized Ratio), which is derived
and weight loss are reported side effects of the from the calibration of commercial thromboplastin
drug. reagents against international reference
preparations. International reference preparations
115.(c) Prozac (Fluoxetine HCL) is a potent and are made from human brain thromboplastins which
selective reuptake inhibitor of serotonin, but not of are more sensitive and accurate.
norepinephrine.
120.(b) Nitroglycerin, an organic nitrate, is a
116.(e) Lactic acidosis and severe hepatomegaly vasodilator which has effects on both arteries and
with steatosis, including fatal cases, have been veins. Nitromist (nitroglycerin) lingual aerosol is a

226