Page 27 - Reference Guide For Foreign Pharmacy Licensing Exam Theory
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The formulation of tablets requires the following pharmaceutical additives:
a. Diluent
b. Adsorbent
c. Binder
d. Disintegrant
e. Glidant
f. Lubricant
g. Anti-adhesive
*(Please refer to Chapter Pharmaceuticals Additives.)
The manufacturing of tablets requires the following steps:
1. Mixing
2. Granulation
3. Compression
4. Coating
The list of the manufacturing defects normally reported with the formulation of tablet:
a. Capping, lamination and chipping
b. Picking and sticking
c. Mottling
a. Capping, lamination and chipping
1. Capping is normally defined as when a tablet is separated partially or completely from the main body.
2. Lamination is defined as when a tablet breaks into two or more layers.
3. Chipping is defined as when a small portion of tablet may come off.
Causes:
1. Entrapment of air within compressed granules.
2. Defective punch or die
Remedies
1. Prevent entrapment of air during granules’ compression.
2. Change defective punch or die.
b. Picking and sticking:
Picking is defined as when ingredients come off from the tablet surfaces and adhere to the face of the punch. It
is normally reported when one tries to print CFR codes on tablets especially with letters like A, B, M or W.
Sticking is defined as when granules adhere to the die wall.
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