Page 54 - Fpgee Question And Answer 2024 Edition

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+
Na CO Na Anion gap = 145 - (105 + 25)
2 3
106 gm contains 46 gm
325 gm contains ? Anion gap = 15

325 x 46 The calculated anion gap = 15(above the normal gap
= = 141 grams
106 of 8-12), therefore it is an elevated anion gap
metabolic acidosis or an anion gap acidosis.
1255. (b) The initial plasma concentration of the
drug is 10mcg/ml and 2.5 mcg/ml concentration
after 16 hours, therefore:

Mcg/ml Hours

10 mcg/ml 0
5 mcg/ml 8 hours
2.5 mcg/ml 8 hours

Total 16 hours

The half-life of the drug should be 8 hours.

1256.(a). If the patient is suffering from metabolic
acidosis (low pH with low HCO 3), the next step is to
calculate the anion gap because the anion gap helps
determining the etiology of the metabolic acidosis.

The anion gap is the difference between the
measured serum cations (positively charged
particles) and the measured serum anions
(negatively charged particles). The commonly
measured cation is sodium and the measured
anions include chloride and bicarbonate.

-
+
-
Anion gap = [Na ] - ([Cl ] + [HCO 3 ])

The normal anion gap value is between 8 and 12. An
anion gap of greater than 12 is considered
"elevated".

The differential diagnosis for an elevated anion gap
metabolic acidosis (simply called "anion gap
acidosis") differs from the differential diagnosis for
non-elevated anion gap metabolic acidosis (simply
called "non-anion gap acidosis").

So, in the above example:

-
+
-
Anion gap = [Na ] - ([Cl ] + [HCO 3 ])

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