Page 25 - Pharmacy Technician Book
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            The % mark-up on a prescription is 15.                11. (b).  Asthma  is  characterized  by  increased
                                                                  responsiveness  of  the  trachea  and  bronchi  to
            Cost for Olanzapine          mark-up on rx            various  stimuli  and  narrowing  of  airways.  It  is
            $100                         $15                      associated  with  shortness  of  breath,  chest
            $4.20                        ?                        tightness,  wheezing  and  coughing.  The  stimulation
                                                                  of  beta-2  receptors  dilates  the  bronchial  smooth
            15x4.20/100 = $0.63, therefore a dispensing cost of   muscles and helps controlling symptoms associated
            each tablet of Olanzapine should be $4.20 + $0.63 =   with  asthma.  The  stimulation  of  beta-1  receptors
            $4.83.                                                increases cardiac output.

            The cost for dispensing 30 tablets should be $4.83 x   Beta-2 receptors blockers may constrict the smooth
            30 = $144.90 = $145.                                  muscles of bronchi and even aggravate asthma.

            9. (b).  33  grams.  For  calculations  of  this  type,  an   Metoprolol  is  a  selective  beta  receptor  blocker
            allegation method is very useful. We should mix 3%    indicated  for  the  treatment  of  hypertension  by
            Salicylic  acid  powder  with  a  talc  powder  (0  %   blocking  beta-1  receptor.  Although  it  has  relative
            Salicylic  acid)  in  such  a  way  that  the  final mixture   beta1  selectivity,  Metoprolol  shall  be  used  with
            would  give  us  500  grams  of  0.2%  Salicylic  acid   caution in patients with bronchospastic disease who
            powder.                                               do  not  respond  to,  or  cannot  tolerate,  other
                                                                  antihypertensive treatment. Since beta1 selectivity
                                                                  is not absolute, a beta2-stimulating agent should be
                                                                  administered  concomitantly,  and  the  lowest
                                                                  possible dose of Metoprolol should be used.

                                                                  The  other  choices,  such  as  Ipratropium,  Albuterol
                                                                  and  Zafirlukast,  are  indicated  for the treatment of
                                                                  asthma.

                                                                  12.(b).  A  prescription  for  Schedule  II  controlled
                                                                  drugs should be dispensed with an exact dispensing
                                                                  quantity  mentioned  on  the  prescription  by  a
            Parts of 0.2% acid           Parts of 3 % acid        prescribing  physician.  MS-Contin  is  a  Schedule  II
            3 parts                          0.2 parts            controlled  drug.  The  correct  dispensing  quantity
            500                          ?                        should be 60.

            500x0.2/3 = 33 grams of 3% salicylic acid.            13. (b).  A  prescription  for  Schedule  III  and  IV
                                                                  controlled  drugs  cannot  be  refilled  more  than  5
            Therefore,  if  we  mix  33  grams  (3%  Salicylic  acid)   times within a period of six months from the date
            with 467 grams talc powder (500 grams - 33 grams      the prescription was issued. A patient must bring a
            = 467 grams), we will get 500 grams of 0.2% Salicylic   new prescription since all the allowable refills were
            acid.                                                 executed.

            10. (b).  Plavix  (Clopidogrel)  is  a  blood  thinning   14.(c). Otocort otic solution is intended for ear use
            agent. Agents of this class generally act by inhibiting   only. It should not be applied to eyes. An auxiliary
            aggregation of platelets, which is thought to be the   label,  “for  ear  use  only”,  should  be  placed  on  the
            primary mechanism of blood clotting. It is indicated   dispensing container.
            for  prevention  of  heart  strokes  in  patients  with
            congestive heart failure (CHF).


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