Page 50 - RxExam's Naplex Theory Review Part-1

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Dose Special Notes

Tenecteplase 3). This fibrin specificity decreases systemic activation of
(Injection) plasminogen and the resulting degradation of circulating
fibrinogen as compared to a molecule lacking this
property.

4). Tenecteplase (TNKase) is indicated for the treatment of
myocardial infarction.

Common Side Effects of Thrombolytic Agents:

1. Bleeding
2. Allergic reactions
3. Intracranial hemorrhage
4. Cholesterol embolization - Clinical features of cholesterol embolism may include livedo reticularis,
"purple toe" syndrome, acute renal failure, gangrenous digits, hypertension, pancreatitis, myocardial
infarction, cerebral infarction, spinal cord infarction, retinal artery occlusion, bowel infarction, and
rhabdomyolysis.

Antiplatelets Agents:

Dose Special Notes

Aspirin 81-325 mg per day. 1). Aspirin (Ecotrin) is prostaglandin and platelet aggregation
(Tablet) Inhibitor.
(Chewable,
Tablet) 2). It is indicated for the prevention of stroke associated with
myocardial infarction.

3). Bleeding, upset stomach and heartburn are reported side
effects of Aspirin.

4). Children and teenagers should not use this medicine for
chicken pox or flu symptoms before a doctor is consulted about
Reye's syndrome, a rare but serious illness reported to be
associated with Aspirin.

Clopidogrel 1. ACS 1). Clopidogrel (Plavix) is an inhibitor of platelet activation and
(Tablet) aggregation through the irreversible binding of its active
75 mg once daily metabolite to the P2Y12 class of ADP receptors on platelets.
administer with
Aspirin (75-325 mg 2). Clopidogrel (Plavix) is indicated for an acute coronary syndrome
once daily) with or (ACS), recent myocardial infarction (MI), recent stroke, or
without food. established peripheral arterial disease (PAD).

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