Page 27 - RxExam's Naplex Theory Book Part 2

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Dose Special Notes

Mycophenolic 4). Constipation, nausea, and urinary tract infection nausea, diarrhea,
Acid nasopharyngitis, multifocal leukoencephalopathy and pure red cell
(Tablet, DR) aplasia are reported side effects of Mycophenolic acid (Myfortic).

5). Female users of childbearing potential must use contraception. Use
of Mycophenolic acid (Myfortic) during pregnancy is associated with
increased risks of pregnancy loss and congenital malformations.

Mycophenolate 1. Renal 1). Mycophenolate mofetil (CellCept), a prodrug of Mycophenolic acid,
Mofetil Transplant: is rapidly absorbed following oral administration and hydrolyzed to
(Tablet) form Mycophenolic acid, which is the active metabolite. Mycophenolic
(Capsule) 1 gram PO or IV acid is an uncompetitive and reversible inhibitor of inosine
(Oral suspension) (over no less than monophosphate dehydrogenase (IMPDH), and therefore inhibits the
(Injection) 2 hours) twice a de novo pathway of guanosine nucleotide synthesis without
day. incorporation to DNA. Because T- and B-lymphocytes are critically
dependent for their proliferation on de novo synthesis of purines,
2. Cardiac Mycophenolic acid has potent cytostatic effects on lymphocytes.
Transplant:
2). Mycophenolate mofetil (CellCept) is indicated for the prophylaxis
1.5 gram PO or IV of organ rejection in patients receiving allogeneic renal, cardiac or
(over no less than hepatic transplants. Mycophenolate mofetil (CellCept) should be used
2 hours) twice a concomitantly with cyclosporine and corticosteroids.
day.
3). Mycophenolate mofetil (CellCept) oral constituted suspension
3. Hepatic should be discarded 60 days after constitution. It should be stored
0
0
Transplant: between 15 and 30 C. Storage in a refrigerator is also acceptable.

1 gram IV (over no 4). Mycophenolate mofetil (CellCept) intravenous solution should
less than 2 hours) never be administered by rapid or bolus intravenous injection.
twice a day OR
1.5 gram PO BID. 5). Constipation, nausea, and urinary tract infection nausea, diarrhea,
nasopharyngitis, multifocal leukoencephalopathy and pure red cell
aplasia are reported side effects of Mycophenolate mofetil (CellCept).

6). Female users of childbearing potential must use contraception. Use
of Mycophenolate mofetil (CellCept) during pregnancy is associated
with increased risk of pregnancy loss and congenital malformations.

Lymphocyte 1). Lymphocyte immune globulin is indicated for the management of
Immune allograft rejection in renal transplant patients. It is also indicated for
Globulin the treatment of moderate to severe aplastic anemia in patients who
(Injection) are unsuitable for bone marrow transplantation.

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