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Which of the following information about Zurampic is/are TRUE? [Select All that apply].

a. Acute liver failure has reported with Zurampic.
b. Zurampic should be used in combination with a xanthine oxidase inhibitor.
c. An active ingredient found in Zurampic is Lesinurad.
d. Zurampic is a xanthine oxidase inhibitor.
e. Zurampic is indicated for the treatment of hyperuricemia associated with gout.


Which of the following information about Zurampic is/are TRUE? [Select All that apply].

a. Acute liver failure has reported with Zurampic.
b. Zurampic should be used in combination with a xanthine oxidase inhibitor.
c. An active ingredient found in Zurampic is Lesinurad.
d. Zurampic is a xanthine oxidase inhibitor.
e. Zurampic is indicated for the treatment of hyperuricemia associated with gout.

Answer: (b,c,e). Zurampic (Lesinurad) is a URAT1 inhibitor. It is available as blue film-coated tablets for oral administration containing 200 mg Lesinurad. It should be used in combination with a xanthine oxidase inhibitor. Lesinurad reduces serum uric acid levels by inhibiting the function of transporter proteins involved in uric acid reabsorption in the kidney. It is indicated in combination with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone.

Zurampic (Lesinurad) is not recommended for the treatment of asymptomatic hyperuricemia. Zurampic (Lesinurad) should not be used as monotherapy.

Zurampic (Lesinurad) tablets are for oral use and should be co-administered with a xanthine oxidase inhibitor, including allopurinol or febuxostat. Zurampic (Lesinurad) is recommended at 200 mg once daily. This is also the maximum daily dose. Zurampic (Lesinurad) should be taken by mouth, in the morning with food and water.

Zurampic (Lesinurad) causes an increase in renal uric acid excretion, which may lead to renal events including transient increases in serum creatinine, renal-related adverse reactions, and kidney stones. These renal events occurred more frequently in patients receiving Zurampic (Lesinurad) 400 mg, when used as monotherapy or in combination with a xanthine oxidase inhibitor. Kidney function is required to monitor.

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