Buy 5 or More Products! Save 25% On Total.
 Buy 3 or More Products! Save 10% On Total.
 Free Shipping! No Minimum Order.

109 listings in all posts with a title or author like "Pharmacy exam"




Blog Empty Image

Patients should be advised to report immediately which of the following signs or symptoms when on Clozapine therapy? [Select ALL THAT APPLY].

a. Lethargy
b. Fever
c. Sore throat
d. Weakness
e. Severe nausea and vomiting


Patients should be advised to report immediately which of the following signs or symptoms when on Clozapine therapy? [Select ALL THAT APPLY].

a. Lethargy
b. Fever
c. Sore throat
d. Weakness
e. Severe nausea and vomiting

Answer: (a,b,c,d). Clozaril (Clozapine), an atypical antipsychotic drug, is indicated for:

1. Treatment-Resistant Schizophrenia
2. Reduction in the Risk of Recurrent Suicidal Behavior in Schizophrenia or Schizoaffective Disorders

Because of a significant risk of agranulocytosis, a potentially Life-threatening adverse event, Clozaril (Clozapine) should be Reserved for use in

(1). the treatment of severely ill patients with Schizophrenia who fail to show an acceptable response to Adequate courses of standard antipsychotic drug treatment,

Or

(2). for reducing the risk of recurrent suicidal behavior in patients With schizophrenia or schizoaffective disorder who are judged to Be at risk of reexperiencing suicidal behavior.
Patients being treated with Clozapine must have a baseline white Blood cell (WBC) count and absolute neutrophil count (ANC) before initiation of treatment as well as regular WBC counts and ANCs during treatment and for at least 4 weeks after Discontinuation of treatment.

Clozapine is available only through a distribution system that Ensures monitoring of WBC count and ANC according to the Schedule described below prior to delivery of the next supply of Medication.

Agranulocytosis, defined as an ANC of less than 500/mm3, has been reported with Clozaril (Clozapine). Patients should be advised to report immediately the appearance of lethargy, weakness, fever, sore throat or any other signs of infection occurring at any time during Clozaril (Clozapine) therapy. Such patients should have a WBC count and ANC performed promptly.


Blog Empty Image

Based on the genetic make-up of SARS-CoV-2, which of the following drug classes is most likely to prove effective?

a. Angiotensin converting enzyme inhibitors
b. Protease inhibitors
c. Nucleoside analogues
d. Neuraminidase inhibitors
e. Calcium channel blockers


Based on the genetic make-up of SARS-CoV-2, which of the following drug classes is most likely to prove effective?

a. Angiotensin converting enzyme inhibitors
b. Protease inhibitors
c. Nucleoside analogues
d. Neuraminidase inhibitors
e. Calcium channel blockers

Answer: (b). The SARS-CoV-2 RNA codes for a pair of protease enzymes that are essential to production of viable virions upon release. Since protease inhibitors have been highly effective for treating patients with infections of human immunodeficiency virus and hepatitis C virus, that is the best choice.

Use of neuraminidase inhibitors (e.g., oseltamivir, peramivir, zanamivir) is not logical, since coronaviruses do not have a gene for neuraminidase.

Nucleoside analogues (e.g., acyclovir, ganciclovir, ribavirin) would be expected to exert effects only at high levels since the coronavirus has an exonuclease that would recognize and remove the analogues when incorporated into the viral genome.

It is currently unknown as to whether angiotensin converting enzyme (ACE) inhibitors or angiotensin-2 receptor blockers (ARBs) are beneficial or harmful based on changes in the ACE2 protein involved in viral entry in lung tissue.



Blog Empty Image

The recommended dose of Olumiant in patients taking strong Organic Anion Transporter 3 (OAT3) inhibitors is _____________.

a. 1 mg once daily
b. 2 mg once daily
c. 3 mg once daily
d. 4 mg once daily
e. Cannot be used with OAT3 inhibitors


The recommended dose of Olumiant in patients taking strong Organic Anion Transporter 3 (OAT3) inhibitors is _____________.

a. 1 mg once daily
b. 2 mg once daily
c. 3 mg once daily
d. 4 mg once daily
e. Cannot be used with OAT3 inhibitors

Answer: (a). The active ingredient found in Olumiant is Baricitinib. It is a Janus kinase (JAK) inhibitor indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more TNF antagonist therapies.

1. The recommended dose of Olumiant (Baricitinib) in patients taking strong Organic Anion Transporter 3 (OAT3) inhibitors (e.g., probenecid) is 1 mg once daily.

2. The recommended dose of Olumiant (Baricitinib) in patients with moderate renal impairment is 1 mg once daily.

3. Olumiant (Baricitinib) is not recommended in patients with severe renal impairment.

4. Olumiant (Baricitinib) is not recommended in patients with severe hepatic impairment.

Try our Naplex QBank. www.pharmacyexam.com **Please note: This type of question will not show up in an MPJE. We are just posting to MPJE group for knowledge.


Blog Empty Image

Which of the following statements would indicate that a patient understands why he is taking Olumiant?

a. "I have vasomotor symptoms associated with menopause."
b. "I have rheumatoid arthritis."
c. "I have hypercalcemia."
d. "I have Paget's disease of bone."
e. "I have migraine headaches associated with menopause."


Which of the following statements would indicate that a patient understands why he is taking Olumiant?

a. "I have vasomotor symptoms associated with menopause."
b. "I have rheumatoid arthritis."
c. "I have hypercalcemia."
d. "I have Paget's disease of bone."
e. "I have migraine headaches associated with menopause."

Answer: b

The active ingredient found in Olumiant is Baricitinib. It is a Janus kinase (JAK) inhibitor indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more TNF antagonist therapies.

The recommended dose of Olumiant is 2 mg once daily.

Upper respiratory tract infections, nausea, herpes simplex, and herpes zoster are commonly reported side effects of the drug.

The drug also has shown promising result for the treatment of Covid-19 infection when administered simultaneously with Remdesivir.Olumiant (Baricitinib) in combination with Veklury (Remdesivir) cuts the median recovery time by about a day, compared to patients treated with Remdesivir alone.


Blog Empty Image

Which of the following statements is/are TRUR ABOUT Covid-19? [Select ALL THAT APPLY]

a. COVID-19 infection often begins with malaise, dry cough, dyspnea, fatigue, and feeling of fever.
b. Covid-19 infection has incubation period of 2- to 14-day.
c. In contrast to the sudden onset people report with influenza, progression of symptoms with Covid-19 virus have a slower onset.
d. During early phases of viral spread, symptoms began an average of 7 days before patients sought medical or emergent care.
e. Fever occurs in 89% Covid-19 symptomatic patients.


Which of the following statements is/are TRUR ABOUT Covid-19? [Select ALL THAT APPLY]

a. COVID-19 infection often begins with malaise, dry cough, dyspnea, fatigue, and feeling of fever.
b. Covid-19 infection has incubation period of 2- to 14-day.
c. In contrast to the sudden onset people report with influenza, progression of symptoms with Covid-19 virus have a slower onset.
d. During early phases of viral spread, symptoms began an average of 7 days before patients sought medical or emergent care.
e. Fever occurs in 89% Covid-19 symptomatic patients.

Answer: (a,b,c,e) The COVID-19 often begins with malaise, dry cough, dyspnea, fatigue, and feeling of fever. It progresses over an 11- to 14-day period. It has incubation period of 2- to 14-day. Some patients have had nausea, vomiting, and diarrhea. In contrast to the sudden onset people report with influenza, progression of symptoms with SARS-CoV-2 have a slower onset. During early phases of viral spread, symptoms began an average of 3.5 days (not 7 days) before patients sought medical or emergent care. Fever occurs in almost all symptomatic patients (89%), cough is very common (68%), and some patients have fatigue (38%), sputum production (33%), shortness of breath (19%), sore throat (14%), and headache (14%).

Try our Naplex QBank. www.pharmacyexam.com **Please note: This type of question will not show up in an MPJE. We are just posting to MPJE group for knowledge.



Blog Empty Image

Liver toxicity with acetaminophen may occur and is a serious, dose-dependent effect. The maximum recommended dosage is:

a. 15mg/kg/day
b. 30mg/kg/day
c. 45mg/kg/day
d. 75mg/kg/day
e. 100mg/kg/day


Liver toxicity with acetaminophen may occur and is a serious, dose-dependent effect. The maximum recommended dosage is:

a. 15mg/kg/day
b. 30mg/kg/day
c. 45mg/kg/day
d. 75mg/kg/day
e. 100mg/kg/day

Answer: (d). Liver toxicity with acetaminophen may occur and is a serious, dose-dependent effect. The maximum recommended dosage is 75 mg/kg/day (adults not to exceed 4 g/d), and products carry warnings about exceeding this dose.

Signs associated with acetaminophen toxicity can mimic influenza symptoms and may include nausea, vomiting, diarrhea, and excessive sweating.

This may lead parents and caregivers to administer more medication to the child. Care should be taken not to exceed this threshold by administering higher doses more frequently than recommended.

In 2011 and 2012, the manufacturer of brand-name Tylenol products voluntarily reduced the maximum daily dosage to 3000 mg (6 tablets), with the dosing interval changed from 2 tablets every 4 to 6 hours to 2 tablets every 6 hours; the maximum daily dosage for Regular Strength Tylenol has been reduced to 3250 mg.

However, generic manufacturers may still have a maximum dose of 4000 mg on the product label.


Blog Empty Image

The probable mechanism of action of Baloxavir Marboxil?

a. HMG-CoA inhibitor
b. Neuraminidase inhibitor
c. Cap-dependent endonuclease inhibitor
d. DNA dependent RNA polymerase inhibitor
e. PABA inhibitor


The probable mechanism of action of Baloxavir Marboxil?

a. HMG-CoA inhibitor
b. Neuraminidase inhibitor
c. Cap-dependent endonuclease inhibitor
d. DNA dependent RNA polymerase inhibitor
e. PABA inhibitor

Answer: (c) The active ingredient found in Xofluza (Baloxavir marboxil) is Baloxavir marboxil. Xofluza (Baloxavir marboxil) is a polymerase acidic (PA) endonuclease inhibitor.

Baloxavir marboxil is a prodrug that is converted by hydrolysis to baloxavir, the active form that exerts anti-influenza virus activity. Baloxavir inhibits the endonuclease activity of the polymerase acidic (PA) protein, an influenza virus-specific enzyme in the viral RNA polymerase complex required for viral gene transcription, resulting in inhibition of influenza virus replication.


Blog Empty Image

Prescription antiviral medications with influenza virus activity may be useful adjuncts in influenza prevention and treatment and are most effective when administered within _______ of symptom onset.

a. 24 hours
b. 48 hours
c. 72 hours
d. 4 days
e. 12 hours



Prescription antiviral medications with influenza virus activity may be useful adjuncts in influenza prevention and treatment and are most effective when administered within _______ of symptom onset.

a. 24 hours
b. 48 hours
c. 72 hours
d. 4 days
e. 12 hours

Answer: (b). Prescription antiviral medications with influenza virus activity may be useful adjuncts in influenza prevention and treatment and are most effective when administered within 48 hours of symptom onset.


Blog Empty Image

In which aspect, Salicylate is different from NSAIDs? [Select ALL THAT APPLY]

a. Provide greater pain control with equivalent doses.
b. May cause GI side effects more frequently than NSAIDs.
c. May inhibit prostaglandin synthesis irreversibly; whereas NSAIDs do reversibly.
d. May cause more renal damage than NSAIDs.
e. Risk of bleeding is more with Salicylate compared to NSAIDs.


In which aspect, Salicylate is different from NSAIDs? [Select ALL THAT APPLY]

a. May provide greater pain control with equivalent doses.
b. May cause more GI side effects than NSAIDs.
c. Inhibits prostaglandin synthesis irreversibly; where NSAIDs do reversibly.
d. May cause more renal damage than NSAIDs.
e. May increase the risk of bleeding more compared to NSAIDs.

Answer (b,c): Salicylates, like NSAIDs, work by inhibiting prostaglandin synthesis by inhibiting both COX-1 and COX-2 enzymes; however, salicylates do so in an irreversible manner, while NSAIDs do so reversibly.

Absorption in the gut is affected by the dosage form, gastric pH, gastric emptying time, dissolution rate, and food/antacids.

Aspirin is widely bioavailable with an onset of analgesia within 30 minutes and lasting 4 to 6 hours.

FDA-approved uses for salicylates include treatment of symptoms for osteoarthritis, rheumatoid arthritis, and other rheumatologic diseases, as well as temporary relief of minor aches and pains associated with backache or muscle aches.

High-dose aspirin (900-1000 mg) has been established as an effective treatment option for acute migraine.

Aspirin causes dyspepsia and GI irritation even more frequently than OTC NSAIDs.

Try our Naplex QBank. www.pharmacyexam.com **Please note: This type of question will not show up in an MPJE. We are just posting to MPJE group for knowledge.


Blog Empty Image

At 1000 mg dose, Acetaminophen is usually effective treating which of the following Migraine related symptoms? [Select ALL THAT APPLY]

a. Nausea
b. Vomiting
c. Blurry vision
d. Photophobia
e. Phonophobia



At 1000 mg dose, Acetaminophen is usually effective treating which of the following Migraine related symptoms?[Select ALL THAT APPLY]

a. Nausea
b. Vomiting
c. Blurry vision
d. Photophobia
e. Phonophobia

Answer: (d,e). Acetaminophen has been shown in studies to reduce pain, as well as improve photophobia and phonophobia in individuals with migraine and tension-type headache. They have not been shown to improve symptoms of nausea, vomiting, or blurry vision with migraine.

Try our Naplex QBank. www.pharmacyexam.com **Please note: This type of question will not show up in an MPJE. We are just posting to MPJE group for knowledge.