Dupixent (Dupilumab) is a fully-human monoclonal antibody that inhibits the signaling of the: [Select ALL THAT APPLY].
 
a. IL-4
b. IL-8
c. IL-13
d. IL-20
e. IL-23

Dupixent (Dupilumab) is a fully-human monoclonal antibody that inhibits the signaling of the: [Select ALL THAT APPLY].
 
a. IL-4
b. IL-8
c. IL-13
d. IL-20
e. IL-23

Answer: a, c

Atopic dermatitis usually develops in early childhood and is more common in people who have a family history of the condition.

The main symptom is a rash that typically appears on the arms and behind the knees, but can also appear anywhere.

The active ingredient found in Dupixent (Dupilumab) is Dupilumab. It is the first biologic medicine for children aged 6 to 11 Years with Moderate-to-Severe Atopic Dermatitis.
Dupixent (Dupilumab) is a fully-human monoclonal antibody that inhibits the signaling of the interleukin-4 (IL-4) and interleukin-13 (IL-13) proteins, and is not an immunosuppressant.

IL-4 and IL-13 are key drivers of the type 2 inflammation that plays a major role in atopic dermatitis, asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP).
Dupixent (Dupilumab) is an interleukin-4 receptor alpha antagonist indicated:

1. for the treatment of patients aged 6 years and older with moderate-to-severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.

2. as an add-on maintenance treatment in patients with moderate-to-severe asthma aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid dependent asthma.

3. as an add-on maintenance treatment in adult patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP).

The recommended dose is an initial dose of 600 mg (two 300 mg injections in different injection sites), followed by 300 mg given every other week.
 
Most common adverse reactions (incidence ≥1%) are injection site reactions, conjunctivitis, blepharitis, oral herpes, keratitis, eye pruritus, other herpes simplex virus infection, and dry eye.

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Which of the following information is the primary gene associated with an increased risk for Ankylosing Spondylitis?
 
a. HLA-B27
b. PRC-201
c. HLB-A27
d. CEA
e. RTP-PY3

Which of the following information is the primary gene associated with an increased risk for Ankylosing Spondylitis?
 
a. HLA-B27
b. PRC-201
c. HLB-A27
d. CEA
e. RTP-PY3

Answer: a

Ankylosing Spondylitis is best known as an arthritis of the joints of the spine, but it frequently affects other joints (e.g, shoulders, hips) and occasionally affects other organs such as the eyes, skin, and intestines (ie, uveitis, psoriasis, and inflammatory bowel disease, respectively).

The etiology of Ankylosing Spondylitis is unknown; however, environmental and genetic factors may play a role in its occurrence.
 
1. Human leukocyte antigen-B27 (HLA-B27) is the primary gene associated with an increased risk for Ankylosing Spondylitis;

2. The presence of interleukin 23R (IL23R) and endoplasmic reticulum aminopeptidase 1 (ERAP1) may also increase risk.

Symptom onset commonly occurs in late adolescence or early adulthood (17-45 years of age) with unilateral or alternating low back and buttock pain or stiffness that improves with activity and worsens with rest.
 
The pain is usually dull and diffuses and progresses gradually over weeks to months. Up to 35% of patients have hip arthritis.
 
 The pain eventually becomes chronic and bilateral in nature and advances to neck pain and stiffness months to years after initial presentation.
 
Of note, symptoms of Ankylosing Spondylitis may initially manifest in a peripheral joint in a minority of patients, more commonly in children, which may lead to the potential for an incorrect diagnosis. 
 
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Which of the following information IS NOT reported symptom of pediatric multisystem inflammatory syndrome?
 
a. fever
b. rash
c. persistent cough
d. swollen lymph nodes
e. belly pain

Which of the following information IS NOT reported symptom of pediatric multisystem inflammatory syndrome?
 
a. fever
b. rash
c. persistent cough
d. swollen lymph nodes
e. belly pain

Answer: c

Though the coronavirus doesn't infect as many children as adults, doctors are alarmed that a growing number of children are becoming sick with a condition called pediatric multisystem inflammatory syndrome, which may be related to the coronavirus.

Symptoms of pediatric multisystem inflammatory syndrome include a fever, rash, swollen lymph nodes, and belly pain, the Health Department said in its advisory.

A persistent cough and breathing troubles, two of the main symptoms of COVID-19, are not listed as symptoms of the condition.

The state Health Department said the condition has similarities to toxic shock syndrome and Kawasaki disease, a childhood illness.

Treatments include steroids, intravenous immunoglobulin, aspirin, antibiotics, and oxygen, sometimes use of a ventilator in the most serious cases.

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Nurtec is indicated for which of the following?

a. Hypertension
b. Gout
c. Migraine
d. Diabetes
e. Rheumatoid arthritis

Nurtec is indicated for which of the following?

a. Hypertension
b. Gout
c. Migraine
d. Diabetes
e. Rheumatoid arthritis

Answer: c

The active ingredient found in Nurtec is Rimegepant. It  is a calcitonin gene-related peptide receptor antagonist indicated for the acute treatment of migraine with or without aura in adults.
 
The recommended dose is 75 mg taken orally, as needed. The maximum dose in a 24-hour period is 75 mg. The safety of treating more than 15 migraines in a 30-day period has not been established.
 
Nausea is the most commonly reported side effect of Nurtec (Rimegepant). 
 
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Phexxi is indicated for the treatment of:
 
a. Hypertension
b. Diabetes
c. Prevention of pregnancy
d. Nausea and vomiting associated with emetogenic cancer therapy
e. Parkinsonism

Phexxi is indicated for the treatment of:
 
a. Hypertension
b. Diabetes
c. Prevention of pregnancy
d. Nausea and vomiting associated with emetogenic cancer therapy
e. Parkinsonism
 
Answer: C

Phexxi is the first non-hormonal, on-demand, vaginal pH regulator contraceptive designed to maintain vaginal pH within the normal range of 3.5 to 4.5 – an acidic environment that is inhospitable to sperm.
 
The active ingredients found in Phexxi are lactic acid, citric acid and potassium bitartrate. It is available as vaginal gel.
 
It is indicated for the prevention of pregnancy in females of reproductive potential for use as an on-demand method of contraception. Phexxi is not effective for the prevention of pregnancy when administered after intercourse.
 
Avoid use of Phexxi in females of reproductive potential with history of recurrent urinary tract infection or urinary tract abnormalities.
 
Vulvovaginal burning sensation, vulvovaginal pruritus, vulvovaginal mycotic infection, urinary tract infection, vulvovaginal discomfort, bacterial vaginosis, vaginal discharge, genital discomfort, dysuria, and vulvovaginal pain are commonly reported side effects of Phexxi.
 
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The CK test is useful to detect which of the following?
 
I. Muscular dystrophy
II. Rhabdomyolysis
III. Heart attacks

a. I only
b. III only
c. I and II only
d. II and III only
e. All

The CK test is useful to detect which of the following?
 
I. Muscular dystrophy
II. Rhabdomyolysis
III. Heart attacks

a. I only
b. III only
c. I and II only
d. II and III only
e. All

Answer: E (All).

The CK test measures the amount of creatine kinase (CK) in the blood. CK is a type of protein, known as an enzyme. It is mostly found in skeletal muscles and heart, with lesser amounts in the brain. Skeletal muscles are the muscles attached to skeleton.

A CK test is most often used to diagnose and monitor muscular injuries and diseases. These diseases include:

1. Muscular dystrophy, a rare inherited disease that causes weakness, breakdown, and loss of function of skeletal muscles. It mostly occurs in males.

2. Rhabdomyolysis, a rapid breakdown of muscle tissue. It can be caused by a serious injury, muscle disease, or other disorder.

3. The test can also be used to help diagnose a heart attack, though not very often. CK testing used to be a common test for heart attacks. 
 
 
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_______________  is characterized by recurrent binge eating episodes during which a person feels a loss of control and marked distress over his or her eating. Binge eating episodes are not followed by purging, excessive exercise or fasting.

a. Binge eating disorder
b. Bulimia Nervosa
c. Anorexia Nervosa
d. High carb eating disorder
e. Low carb eating disorder

_______________  is characterized by recurrent binge eating episodes during which a person feels a loss of control and marked distress over his or her eating. Binge eating episodes are not followed by purging, excessive exercise or fasting.

a. Binge eating disorder
b. Bulimia Nervosa
c. Anorexia Nervosa
d. High carb eating disorder
e. Low carb eating disorder

Answer: a

1. Binge eating disorder is characterized by recurrent binge eating episodes during which a person feels a loss of control and marked distress over his or her eating.
Unlike bulimia nervosa, binge eating episodes are not followed by purging, excessive exercise or fasting. As a result, people with binge eating disorder often are overweight or obese.
 
2. Bulimia nervosa is characterized by binge eating (eating large amounts of food in a short time, along with the sense of a loss of control) followed by a type of behavior that compensates for the binge, such as purging (e.g., vomiting, excessive use of laxatives, or diuretics), fasting, and/or excessive exercise.

Unlike anorexia nervosa, people with bulimia can fall within the normal range for their weight. But like people with anorexia, they often fear gaining weight, want desperately to lose weight, and are intensely unhappy with their body size and shape.
 
3. Anorexia nervosa is characterized by a significant and persistent reduction in food intake leading to extremely low body weight in the context of age, sex, and physical health; a relentless pursuit of thinness; a distortion of body image and intense fear of gaining weight; and extremely disturbed eating behavior.

Many people with anorexia see themselves as overweight, even when they are starved or severely malnourished.
 

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WARNING!

Please be aware of the scam, originally brought to our attention by one of our customer. This company website URL is rx-exam.com. The website phone number is 123-456-7890 - which itself suggests it is a fraud. They are claiming to sell materials from their websites for various pharmacy related exams. All materials are offered for online purchase. Many customers have lost their money since after purchasing using credit cards; they don't receive any material.

Please DO NOT PURCHASE any material from this site www.rx-exam.com.

PharmacyExam (RxExam) is not affiliated with this company and bears no responsibility for any financial loss. Please pass this message to your friends. The authenticated web site for our company is www.pharmacyexam.com

Thank you.

Founder and President

Manan Shroff

WARNING!

Please be aware of the scam, originally brought to our attention by one of our customer.This company website URL is rx-exam.com. The website phone number is 123-456-7890 - which itself suggests it is a fraud.They are claiming to sell materials from their websites for various pharmacy related exams. All materials are offered for online purchase. Many customers have lost their money since after purchasing using credit cards; they don't receive any material.

PleaseDO NOT PURCHASEany material from this sitewww.rx-exam.com.

PharmacyExam (RxExam) is not affiliated with this company and bears no responsibility for any financial loss. Please pass this message to your friends. The authenticated web site for our company iswww.pharmacyexam.com

Thank you.

Founder and President

Manan Shroff

Test 3

Test 3

Veklury must be administered:

a. IV infusion
b. Subcutaneously
c. Intramuscularly
d. Orally
e. Rectally

Veklury must be administered:

a. IV infusion
b. Subcutaneously
c. Intramuscularly
d. Orally
e. Rectally

Answer: (a). The active ingredient found in Veklury is Remdesivir. Veklury (Remdesivir) is authorized for use under an Emergency Use Authorization (EUA) only for the treatment of adult and pediatric patients hospitalized with suspected or laboratory-confirmed COVID-19, and for whom use of an intravenous (IV) agent is clinically appropriate. Veklury must be administered via IV infusion. It is only administered intravenously in a hospital setting under the care of a physician.

Remdesivir is an adenosine nucleotide prodrug that distributes into cells where it is metabolized to form the pharmacologically active nucleoside triphosphate metabolite. Metabolism of Remdesivir to Remdesivir triphosphate has been demonstrated in multiple cell types. Remdesivir triphosphate acts as an analog of adenosine triphosphate (ATP) and competes with the natural ATP substrate for incorporation into nascent RNA chains by the SARS-CoV-2 RNA-dependent RNA polymerase, which results in delayed chain termination during replication of the viral RNA. Remdesivir triphosphate is a weak inhibitor of mammalian DNA and RNA polymerases with low potential for mitochondrial toxicity.

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