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A pharmacist receives a new prescription for Augmentin 500 mg. The prescription reads 1 tab po bid x 10 days. A technician in the pharmacy fills and processes the prescription using 250 mg of Augmentin instead, since the pharmacy is out of stock of 500 mg Augmentin tablets. The pharmacist who is doing the final check of the prescription should:

a. Fill the prescription as it is.
b. Call the physician and get approval regarding this switch.
c. Not fill the prescription.
d. Fill the prescription but counsel and inform the patient about this switch.

Answer:


A pharmacist receives a new prescription for Augmentin 500 mg. The prescription reads 1 tab po bid x 10 days. A technician in the pharmacy fills and processes the prescription using 250 mg of Augmentin instead, since the pharmacy is out of stock of 500 mg Augmentin tablets. The pharmacist who is doing the final check of the prescription should:

a. Fill the prescription as it is.
b. Call the physician and get approval regarding this switch.
c. Not fill the prescription.
d. Fill the prescription but counsel and inform the patient about this switch.

Answer: (c) Since both the 250 mg and 500 mg tablets of amoxicillin/clavulanate potassium contain the same amount of clavulanic acid (125 mg, as the potassium salt), two amoxicillin/clavulanate potassium 250 mg tablets are not equivalent to one 500 mg amoxicillin/clavulanate potassium tablet.

Therefore two 250 mg amoxicillin/clavulanate potassium tablets should not be substituted for one 500 mg amoxicillin/clavulanate potassium tablet.

**This question is taken from Clinical Naplex Test-5. Visit www.pharmacyexam.com**


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Which of the following statements is NOT TRUE about vaccines or immunizations?

a. Two live vaccines may be given at the same time.
b. parenteral or intranasal administration of a live vaccine is not thought to affect the immune response of a subsequently administered oral live vaccine.
c. A live vaccine and an inactivated vaccine can be administered without regard to the timing of the other.
d. Antipyretics/analgesics such as acetaminophen or ibuprofen should routinely be given prior to immunization to reduce the discomfort.


Which of the following statements is NOT TRUE about vaccines or immunizations?

a. Two live vaccines may be given at the same time.
b. parenteral or intranasal administration of a live vaccine is not thought to affect the immune response of a subsequently administered oral live vaccine.
c. A live vaccine and an inactivated vaccine can be administered without regard to the timing of the other.
d. Antipyretics/analgesics such as acetaminophen or ibuprofen should routinely be given prior to immunization to reduce the discomfort.

Answer:(d). If more than one non-oral live vaccine (e.g., live attenuated influenza vaccine [LAIV], varicella, mumps) needs to be administered, it is recommended that the vaccines be given on the same day. However, if this is not possible, doses of the live vaccines should be separated by at least four weeks. The four-week interval reduces the interference of immune response to the first vaccine by the second vaccine.
 
This rule for separation does not apply to the administration of oral live vaccines not given on the same day: typhoid and rotavirus. These vaccines can be given less than four weeks apart. However, this scenario isn't likely to occur because the age groups for which these vaccines are recommended do not overlap. In addition, parenteral or intranasal administration of a live vaccine is not thought to affect the immune response of a subsequently administered oral live vaccine.
 
A live vaccine and an inactivated vaccine can be administered without regard to the timing of the other.
 
Antipyretics/analgesics such as acetaminophen or ibuprofen should not routinely be given prior to immunization. They might reduce a patient's immune response. However, if needed, these meds can be used for treatment of fever and pain as needed following vaccination.

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A consulting pharmacist in a skilled nursing facility is asked by a nurse: "What is meant by peak digoxin body stores in the following chart order?" The patient has received the following new orders:

Lanoxin (Digoxin)

Administer (immediately) a dose to get peak digoxin body stores of 10 mcg/kg. Administer a second dose 6 hours later, after confirming with the prescriber.

The pharmacist may tell her that:

a. He hasn't heard of it before.
b. It means a loading dose of the drug.
c. It means a maintenance dose of the drug.
d. It should be clarified with the prescribing physician.
e. It means AUC at t1/2.

Answer:

**This sample question is from Clinical NAPLEX Practice Test 3.** For more information please visit www.pharmacyexam.com


A consulting pharmacist in a skilled nursing facility is asked by a nurse: "What is meant by peak digoxin body stores in the following chart order?" The patient has received the following new orders:

Lanoxin (Digoxin)

Administer (immediately) a dose to get peak digoxin body stores of 10 mcg/kg. Administer a second dose 6 hours later, after confirming with the prescriber.

The pharmacist may tell her that:

a. He hasn't heard of it before.
b. It means a loading dose of the drug.
c. It means a maintenance dose of the drug.
d. It should be clarified with the prescribing physician.
e. It means AUC at t1/2.

Answer:(b). Digitalization may be accomplished by either of two general approaches that vary in dosage and frequency of administration, but reach the same endpoint in terms of total amount of digoxin accumulated in the body.

If rapid digitalization is considered medically appropriate, it may be achieved by administering a loading dose based upon projected peak digoxin body stores. Maintenance doses can be calculated as a percentage of the loading dose.

Peak digoxin body stores (i.e. loading dose) of 8 to 12 mcg/kg should provide therapeutic effect with minimum risk of toxicity in most patients with heart failure and normal sinus rhythm. Because of altered digoxin distribution and elimination, projected peak body stores for patients with renal insufficiency should be conservative (i.e. 6 to 10 mcg/kg).

The loading dose should be administered in several portions, with roughly half the total given as the first dose. Additional fractions of this planned total dose may be given at 6- to 8-hour intervals, with careful assessment of clinical response before each additional dose.

**This sample question is from Clinical NAPLEX Practice Test 3.** For more information please visit www.pharmacyexam.com


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Which of the following information regarding Pneumovax 23 is TRUE?
 
a. Pneumococcal vaccine is administered intradermally as one 0.5-mL dose.
b. Pneumococcal vaccine MUST NOT be administered at the same time as influenza vaccine.
c. For any person who has received a dose of pneumococcal vaccine at age greater than 65 years, revaccination is not indicated.
d. PNEUMOVAX 23 is approved for use in children older than 1 year of age.


Which of the following information regarding Pneumovax 23 is TRUE?
 
a. Pneumococcal vaccine is administered intradermally as one 0.5-mL dose.
b. Pneumococcal vaccine MUST NOT be administered at the same time as influenza vaccine.
c. For any person who has received a dose of pneumococcal vaccine at age greater than 65 years, revaccination is not indicated.
d. PNEUMOVAX 23 is approved for use in children older than 1 year of age.
 
Answer:(c). PNEUMOVAX 23 is a vaccine indicated for active immunization for the prevention of pneumococcal disease caused by the 23 serotypes contained in the vaccine.
 
PNEUMOVAX 23 is NOT approved for use in children younger than 2 years of age because children in this age group do not develop an effective immune response to capsular types contained in the polysaccharide vaccine.
 
The Advisory Committee on Immunization Practices (ACIP) has recommendations for revaccination against pneumococcal disease for persons at high risk who were previously vaccinated with PNEUMOVAX 23. Routine revaccination of immunocompetent persons previously vaccinated with a 23-valent vaccine, is not recommended.
 
All persons in this category should receive the pneumococcal vaccine, including previously unvaccinated persons and persons who have not received vaccine within 5 years (and were <65 years of age at the time of vaccination). For any person who has received a dose of pneumococcal vaccine at age greater than 65 years, revaccination is not indicated.
 
Pneumococcal vaccine is administered intramuscularly or subcutaneously as one 0.5-mL dose. Pneumococcal vaccine may be administered at the same time as influenza vaccine (by separate injection in the other arm) without an increase in side effects or decreased antibody response to either vaccine.

Pneumococcal vaccine also may be administered concurrently with other vaccines. The administration of pneumococcal vaccine with combined diphtheria, tetanus, and pertussis (DTP); poliovirus; or other vaccines does not increase the severity of reactions or diminish antibody responses.
 
Canadian and U.S. product labeling do say to consider separating administration of Zostavax and Pneumovax 23 by at least four weeks, since concurrent administration of these vaccines can reduce patients' immune responses to Zostavax.

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What would be the new Acetaminophen strength in a reformulated Vicodin?
 
a. 500 mg
b. 300 mg
c. 325 mg
d. None of the above


What would be the new Acetaminophen strength in a reformulated Vicodin?
 
a. 500 mg
b. 300 mg
c. 325 mg
d. None of the above
 
Answer(b): 300 mg. On January 13, 2011, the U.S. Food and Drug Administration (FDA) asked drug manufacturers to limit the strength of acetaminophen in prescription drug products, including combination acetaminophen and opioid products, to no more than 325 mg per dosage unit.
 
The FDA has stated that limiting the amount of acetaminophen per dosage unit in prescription products may reduce the risk of severe liver injury from acetaminophen overdosing.
 
The FDA requested this change be effected by January 2014. Abbott, the manufacturer of Vicodin, has complied with this directive ahead of the FDA's requested date and has introduced new formulations of Vicodin (Hydrocodone bitartrate and Acetaminophen tablets, USP) with reduced acetaminophen content in the third quarter of 2012.
 
Vicodin is available in the following new formulations:

1. VICODIN® (hydrocodone bitartrate and acetaminophen tablets, USP) 5 mg/300 mg
2. VICODIN ES® (hydrocodone bitartrate and acetaminophen tablets, USP) 7.5 mg/300 mg
3. VICODIN HP® (hydrocodone bitartrate and acetaminophen tablets, USP) 10 mg/300 mg
 
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Brintellix is indicated for the treatment of:
 
a. Hypertension
b. Major Depressive Disorder
c. Arthritis
d. Diabetes mellitus
e. Male pattern baldness


Brintellix is indicated for the treatment of:
 
a. Hypertension
b. Major Depressive Disorder
c. Arthritis
d. Diabetes mellitus
e. Male pattern baldness

Answer(b): Major depressive disorder. The active ingredient found in Vortioxetine (Brintellix) is Vortioxetine. Each Vortioxetine (Brintellix) tablet contains 5 mg, 10 mg, 15 mg, or 20 mg of Vortioxetine, respectively. Vortioxetine (Brintellix) is indicated for the treatment of major depressive disorder (MDD).
 
The recommended starting dose is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated, because higher doses demonstrated better treatment effects in trials conducted in the United States. The efficacy and safety of doses above 20 mg/day have not been evaluated in controlled clinical trials. A dose decrease down to 5 mg/day may be considered for patients who do not tolerate higher doses.
 
At least 14 days should elapse between discontinuation of a MAOI intended to treat psychiatric disorders and initiation of therapy with Vortioxetine (Brintellix) to avoid the risk of Serotonin Syndrome. Conversely, at least 21 days should be allowed after stopping Vortioxetine (Brintellix) before starting an MAOI intended to treat psychiatric disorders.
 
Nausea, constipation, vomiting, serotonin toxicity and serotonin syndrome are commonly reported side effects of Vortioxetine (Brintellix).
 
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Which of the following drugs shall be strictly avoided in a patient taking Paxil?
 
a. Lyrica
b. MS Contin
c. Brisdelle
d. Astagraf
e. Depakote


Which of the following drugs shall be strictly avoided in a patient taking Paxil?
 
a. Lyrica
b. MS Contin
c. Brisdelle
d. Astagraf
e. Depakote

Answer:(c) Paroxetine (Brisdelle) is an orally administered selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause. Each pink capsule contains 7.5 mg Paroxetine base.
 
The recommended dosage of Paroxetine (Brisdelle) for the treatment of moderate to severe VMS is 7.5 mg once daily, at bedtime, with or without food.
 
Paroxetine (Brisdelle) is not indicated for the treatment of any psychiatric condition. Paroxetine (Brisdelle) contains a lower dose of paroxetine than that used to treat depression, obsessive compulsive disorder, panic disorder, generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder.
 
Serotonin syndrome, abnormal bleeding, hyponatremia, mania/hypomania, seizure and suicidal thoughts and behavior are reported side effects of Paroxetine (Brisdelle).

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Which of the following is the principal side effect of Zaltrap?
 
a. Tachycardia
b. Seizure
c. G.I perforation and bleeding
d. Ocular hypertension
e. Diarrhea


Which of the following is the principal side effect of Zaltrap?
 
a. Tachycardia
b. Seizure
c. G.I perforation and bleeding
d. Ocular hypertension
e. Diarrhea
 
Answer:(c). Ziv-aflibercept (Zaltrap) is a recombinant fusion protein consisting of Vascular Endothelial Growth Factor (VEGF)-binding portions from the extracellular domains of human VEGF Receptors 1 and 2 fused to the Fc portion of the human IgG1.
 
Ziv-aflibercept (Zaltrap), in combination with 5-fluorouracil, leucovorin, irinotecan-(FOLFIRI), is indicated for patients with metastatic colorectal cancer (mCRC) that is resistant to or has progressed following an oxaliplatin-containing regimen.
 
Administer Ziv-aflibercept (Zaltrap) 4 mg per kg as an intravenous (IV) infusion over 1 hour every two weeks. Administer Ziv-aflibercept (Zaltrap) prior to any component of the FOLFIRI regimen on the day of treatment.
 
Severe and sometimes fatal hemorrhage, including gastrointestinal (GI) hemorrhage, has been reported in the patients who have received Ziv-aflibercept (Zaltrap) in combination with FOLFIRI. Monitor patients for signs and symptoms of GI bleeding and other severe bleeding. Do not administer Ziv-aflibercept (Zaltrap) to patients with severe hemorrhage.
 
Gastrointestinal Perforation: Gastrointestinal (GI) perforation including fatal GI perforation can occur in patients receiving Ziv-aflibercept (Zaltrap). Discontinue Ziv-aflibercept (Zaltrap) therapy in patients who experience GI perforation.
 
Severe compromised wound healing can occur in patients receiving ZALTRAP/FOLFIRI. Discontinue Ziv-aflibercept (Zaltrap) in patients with compromised wound healing. Suspend Ziv-aflibercept (Zaltrap) for at least 4 weeks prior to elective surgery, and do not resume Ziv-aflibercept (Zaltrap) for at least 4 weeks following major surgery and until the surgical wound is fully healed.
 
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Levomilnacipran is indicated for the treatment of:
 
a. Hypertension
b. Depression
c. Epilepsy
d. Renal carcinoma
e. Arrhythmia


Levomilnacipran is indicated for the treatment of:
 
a. Hypertension
b. Depression
c. Epilepsy
d. Renal carcinoma
e. Arrhythmia

Answer:(b). Levomilnacipran (Fetzima), a selective serotonin and norepinephrine reuptake inhibitor (SNRI), is indicated for the treatment of major depressive disorder (MDD).
 
The recommended dose range for Levomilnacipran (Fetzima) is 40 mg to 120 mg once daily, with or without food. Levomilnacipran (Fetzima) should be initiated at 20 mg once daily for 2 days and then increased to 40 mg once daily. Based on efficacy and tolerability, Levomilnacipran (Fetzima) may then be increased in increments of 40 mg at intervals of 2 or more days. The maximum recommended dose is 120 mg once daily.
 
At least 14 days should elapse between discontinuation of an MAOI intended to treat psychiatric disorders and initiation of therapy with Levomilnacipran (Fetzima). Conversely, at least 7 days should be allowed after stopping Levomilnacipran (Fetzima) before starting an MAOI antidepressant.
 
Suicidal thoughts and behaviors in adolescents and young adults, serotonin syndromes, elevated blood pressure, activation of mania/hypomania, seizure and hyponatremia are reported side effects of Levomilnacipran.

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Please DO NOT PURCHASE any material from this site www.rx-exam.com.

PharmacyExam (RxExam) is not affiliated with this company and bears no responsibility for any financial loss. Please pass this message to your friends. The authenticated web site for our company is www.pharmacyexam.com

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Founder and President

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WARNING!

Please be aware of the scam, originally brought to our attention by one of our customer.This company website URL is rx-exam.com. The website phone number is 123-456-7890 - which itself suggests it is a fraud.They are claiming to sell materials from their websites for various pharmacy related exams. All materials are offered for online purchase. Many customers have lost their money since after purchasing using credit cards; they don't receive any material.

PleaseDO NOT PURCHASEany material from this sitewww.rx-exam.com.

PharmacyExam (RxExam) is not affiliated with this company and bears no responsibility for any financial loss. Please pass this message to your friends. The authenticated web site for our company iswww.pharmacyexam.com

Thank you.

Founder and President

Manan Shroff




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