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Which of the following information about Naloxone Auto-Injector (Evzio) is/are TRUE?
 
I. It is indicated for treating a suspected opioid overdose.
 
II. The principal advantage of Naloxone is that it doesn't cause withdrawal symptoms such as sweating, increased heart rate or agitation even in an opioid dependent patient.
 
III. A person should use great caution to administer Naloxone to someone who is not using opioids.
 
a. I only
b. I and II only
c. All
d. None of the above


Which of the following information about Naloxone Auto-Injector (Evzio) is/are TRUE?
 
I. It is indicated for treating a suspected opioid overdose.
 
II. The principal advantage of Naloxone is that it doesn't cause withdrawal symptoms such as sweating, increased heart rate or agitation even in an opioid dependent patient.
 
III. A person should use great caution to administer Naloxone to someone who is not using opioids.
 
a. I only
b. I and II only
c. All
d. None of the above

Answer: (a) I is True only. Naloxone HCL (Evzio) is a pre-filled, single-use auto-injector. Naloxone HCL (Evzio) is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression.
 
Naloxone HCL (Evzio) is intended for immediate administration as emergency therapy in settings where opioids may be present. It is for intramuscular and subcutaneous use only. Administer the initial dose of Naloxone HCL (Evzio) to adult or pediatric patients intramuscularly or subcutaneously into the anterolateral aspect of the thigh, through clothing if necessary. There's no harm in giving Naloxone HCL (Evzio) to someone who is not using opioids.
 
Naloxone HCL (Evzio) can trigger withdrawal symptoms such as sweating, increased heart rate, or agitation in the opioid dependent patient. Hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnea, pulmonary edema, and cardiac arrest are commonly reported side effects of Naloxone HCl (Evzio).


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A pharmacist receives a new prescription to compound each capsule such a way so that it contains 200mg Acetaminophen, 50mg Butalbital and 40mg Caffeine. The final formulation of this compounded prescription shall be classified as:
 
a. Schedule III controlled drug
b. Schedule IV controlled drug
c. Schedule V controlled drug
d. Non-controlled substance


A pharmacist receives a new prescription to compound each capsule such a way so that it contains 200mg Acetaminophen, 50mg Butalbital and 40mg Caffeine. The final formulation of this compounded prescription shall be classified as:
 
a. Schedule III controlled drug
b. Schedule IV controlled drug
c. Schedule V controlled drug
d. Non-controlled substance

Answer (a): Schedule III controlled drug, [Section 811(g)(3)(A) Controlled Substances Act].

To be exempt from controlled substance requirement, the ratio of Acetaminophen to Butalbital is set to 70:15. In other words, for every 15mg Butalbital, there shall be at least 70 mg or more Acetaminophen required to exempt the formulation from controlled substance requirement.

In above prescription, the quantity of Butalbital is 50 mg; to exempt it from controlled substance requirement, we need to mix it with at least 233 mg or more Acetaminophen. The prescriber has requested Acetaminophen quantity to be set to 200mg; therefore the final formulation shall be classified as Schedule III controlled substance.

**Please note: Butalbital is classified as Schedule III controlled drug under the DEA. **
 
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Which of the following statements about methamphetamine is/are TRUE?
 
I. Methamphetamine is a highly addictive drug that can be manufactured in small and portable laboratories.

II. The use of methamphetamine can result in fatal kidney and lung disorders, brain damage, liver damage and blood clots.

III. Each pound of methamphetamine produced leaves behind five to six pounds of toxic waste.

IV. Children born to mothers who are abusers of methamphetamine can be born addicted and suffer birth defects, low birth weight, tremors, excessive crying, attention deficit disorder and behavior disorders.
 
a. I only
b. I and IV only
c. II only
d. All


Which of the following statements about methamphetamine is/are TRUE?
 
I. Methamphetamine is a highly addictive drug that can be manufactured in small and portable laboratories.

II. The use of methamphetamine can result in fatal kidney and lung disorders, brain damage, liver damage and blood clots.

III. Each pound of methamphetamine produced leaves behind five to six pounds of toxic waste.

IV. Children born to mothers who are abusers of methamphetamine can be born addicted and suffer birth defects, low birth weight, tremors, excessive crying, attention deficit disorder and behavior disorders.
 
a. I only
b. I and IV only
c. II only
d. All
 
Answer: (d) All. The illegal production and distribution of methamphetamine is an increasing problem nationwide. The methamphetamine is a highly addictive drug that can be manufactured in small and portable laboratories. These laboratories are operated by individuals who manufacture the drug in a clandestine and unsafe manner, often resulting in explosions and fires that can injure not only the individuals involved, but their families, neighbors, law-enforcement officers and firemen.
 
The use of methamphetamine can result in fatal kidney and lung disorders, brain damage, liver damage, blood clots, chronic depression, hallucinations, violent and aggressive behavior, malnutrition, disturbed personality development, deficient immune system and psychosis. Children born to mothers who are abusers of methamphetamine can be born addicted and suffer birth defects, low birth weight, tremors, excessive crying, attention deficit disorder and behavior disorders.
 
In addition to the physical consequences to an individual who uses methamphetamine, usage of the drug also produces an increase in automobile accidents, explosions and fires, increased criminal activity, increased medical costs due to emergency room visits, increases in domestic violence, increased spread of infectious diseases and a loss in worker productivity.
 
That environmental damage is another consequence of the methamphetamine epidemic. Each pound of methamphetamine produced leaves behind five to six pounds of toxic waste. Chemicals and byproducts that result from the manufacture of methamphetamine are often poured into plumbing systems, storm drains or directly onto the ground. Clean up of methamphetamine laboratories is extremely resource-intensive, with an average remediation cost of five thousand dollars.

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A pharmacist, dispensing prescriber, or veterinarian who dispenses a prescription drug which is a controlled substance listed in schedules 2 to 5 shall transmit the data by electronic media or other means as approved by the State Pharmacy Board. The requested data shall be transmitted in the format established by the:
 
a. AHSP
b. PDRQ
c. ASAP
d. CRDD


A pharmacist, dispensing prescriber, or veterinarian who dispenses a prescription drug which is a controlled substance listed in schedules 2 to 5 shall transmit the data by electronic media or other means as approved by the State Pharmacy Board. The requested data shall be transmitted in the format established by the:
 
a. AHSP
b. PDRQ
c. ASAP
d. CRDD

Answer: (c), American Society for Automation in Pharmacy (ASAP).
 
A pharmacist, dispensing prescriber, or veterinarian who dispenses a prescription drug which is a controlled substance listed in schedules 2 to 5 shall transmit the data by electronic media or other means as approved by the State Pharmacy Board. The requested data shall be transmitted in the format established by the American Society for Automation in Pharmacy (ASAP) telecommunications format for controlled substances.


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A pharmacist is reviewing a new prescription prepared by a pharmacy technician. The prescription label reads: Precose 25mg PO TID x 30 days; Qty: 90 5 Refills. Which of the following acts done by the pharmacist is the most appropriate?
 
a. Fill as it is.
b. Call the prescriber to verify the Precose dose.
c. Call the prescriber to verify the number of refills.
d. Ask the technician to add an auxiliary label: "Take With Meals".
e. Counsel the patient that this drug may cause "Severe Constipation".


A pharmacist is reviewing a new prescription prepared by a pharmacy technician. The prescription label reads: Precose 25mg PO TID x 30 days; Qty: 90 5 Refills. Which of the following acts done by the pharmacist is the most appropriate?
 
a. Fill as it is.
b. Call the prescriber to verify the Precose dose.
c. Call the prescriber to verify the number of refills.
d. Ask the technician to add an auxiliary label: "Take With Meals".
e. Counsel the patient that this drug may cause "Severe Constipation".
 
Answer: d. Acarbose (Precose) is an oral alpha-glucosidase inhibitor for use in the management of type 2 diabetes mellitus. It delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, Precose reduces levels of glycosylated hemoglobin in patients with type 2 diabetes mellitus.
 
In contrast to sulfonylureas, Precose does not enhance insulin secretion. The antihyperglycemics action of acarbose results from a competitive, reversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine, while the membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia.
 
The recommended starting dosage of Acarbose (Precose) is 25 mg given orally three times daily at the start (with the first bite) of each main meal . However, some patients may benefit from more gradual dose titration to minimize gastrointestinal side effects. This may be achieved by initiating treatment at 25 mg once per day and subsequently increasing the frequency of administration to achieve 25 mg t.i.d.
 
Hypoglycemia, gas, bloating and diarrhea are commonly reported side effects of Acarbose (Precose).

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For compounding purposes, if neither USP/NF grade substances nor FDA-approved substances are available, or when food, cosmetics, or other substances are, or must be used, the substance shall be of a chemical grade from:
 
I. Chemically Pure
II. Analytical Reagent
III. American Chemical Society
 
a. I only
b. I and II only
c. II and III only
d. All


For compounding purposes, if neither USP/NF grade substances nor FDA-approved substances are available, or when food, cosmetics, or other substances are, or must be used, the substance shall be of a chemical grade from:
 
I. Chemically Pure
II. Analytical Reagent
III. American Chemical Society
 
a. I only
b. I and II only
c. II and III only
d. All

Answer: (d) All. Ingredients used in a compounded preparation shall either originate from FDA-approved sources, if available, or be USP/NF grade substances. If neither USP/NF grade substances nor FDA-approved substances are available, or when food, cosmetics, or other substances are, or must be used, the substance shall be of a chemical grade in one of the following categories:
 
(1). Chemically Pure (CP); 
(2). Analytical Reagent (AR); or 
(3). American Chemical Society (ACS); or 
(4). Food Chemical Codex.
 


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Who may fall to a major statin benefit groups?
 
I. Patients with LDL 190 mg/dL or higher.
II. Patients age 40 to 75 years of age with diabetes and LDL 70 to 189 mg/dL.
III. Patients without clinical atherosclerotic cardiovascular disease or diabetes with LDL 70 to 189 mg/dL.

a. I only
b. I and II only
c. II and III only
d. All


Who may fall to a major statin benefit groups?
 
I. Patients with LDL 190 mg/dL or higher.
II. Patients age 40 to 75 years of age with diabetes and LDL 70 to 189 mg/dL.
III. Patients without clinical atherosclerotic cardiovascular disease or diabetes with LDL 70 to 189 mg/dL.
 
a. I only
b. I and II only
c. II and III only
d. All
 
Answer: d, All. There are four major statin benefit groups:

a. Patients with clinical atherosclerotic cardiovascular disease.

b. Patients with LDL 190 mg/dL (5 mmol/L) or higher.

c. Patients age 40 to 75 years of age with diabetes (but without clinical atherosclerotic cardiovascular disease) and LDL 70 to 189 mg/dL (1.8 to 4.9 mmol/L).

d. Patients without clinical atherosclerotic cardiovascular disease or diabetes with LDL 70 to 189 mg/dL (1.8 to 4.9 mmol/L), with an estimated 10-year risk of atherosclerotic cardiovascular disease of 7.5% or higher.

If a patient does not fit into one of the four statin benefit groups (e.g., LDL 70 to 189 mg/dL [1.8 to 4.9 mmol/L] with 10-year risk 5% to 7.5%), but there is clinical suspicion that they may benefit from a statin, additional factors can be taken into consideration:

a. LDL 160 mg/dL or higher or other evidence of genetic hyperlipidemia.

b. Cardiovascular disease onset in a first degree male relative before age 55, or in a first degree female relative before age 65.

c. High-sensitivity C-reactive protein 2 mg/dL or higher.

d. Elevated lifetime risk of atherosclerotic cardiovascular disease.

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WARNING!

Please be aware of the scam, originally brought to our attention by one of our customer. This company website URL is rx-exam.com. The website phone number is 123-456-7890 - which itself suggests it is a fraud. They are claiming to sell materials from their websites for various pharmacy related exams. All materials are offered for online purchase. Many customers have lost their money since after purchasing using credit cards; they don't receive any material.

Please DO NOT PURCHASE any material from this site www.rx-exam.com.

PharmacyExam (RxExam) is not affiliated with this company and bears no responsibility for any financial loss. Please pass this message to your friends. The authenticated web site for our company is www.pharmacyexam.com

Thank you.

Founder and President

Manan Shroff


WARNING!

Please be aware of the scam, originally brought to our attention by one of our customer.This company website URL is rx-exam.com. The website phone number is 123-456-7890 - which itself suggests it is a fraud.They are claiming to sell materials from their websites for various pharmacy related exams. All materials are offered for online purchase. Many customers have lost their money since after purchasing using credit cards; they don't receive any material.

PleaseDO NOT PURCHASEany material from this sitewww.rx-exam.com.

PharmacyExam (RxExam) is not affiliated with this company and bears no responsibility for any financial loss. Please pass this message to your friends. The authenticated web site for our company iswww.pharmacyexam.com

Thank you.

Founder and President

Manan Shroff


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Test 3


Test 3


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Veklury must be administered:

a. IV infusion
b. Subcutaneously
c. Intramuscularly
d. Orally
e. Rectally


Veklury must be administered:

a. IV infusion
b. Subcutaneously
c. Intramuscularly
d. Orally
e. Rectally

Answer: (a). The active ingredient found in Veklury is Remdesivir. Veklury (Remdesivir) is authorized for use under an Emergency Use Authorization (EUA) only for the treatment of adult and pediatric patients hospitalized with suspected or laboratory-confirmed COVID-19, and for whom use of an intravenous (IV) agent is clinically appropriate. Veklury must be administered via IV infusion. It is only administered intravenously in a hospital setting under the care of a physician.

Remdesivir is an adenosine nucleotide prodrug that distributes into cells where it is metabolized to form the pharmacologically active nucleoside triphosphate metabolite. Metabolism of Remdesivir to Remdesivir triphosphate has been demonstrated in multiple cell types. Remdesivir triphosphate acts as an analog of adenosine triphosphate (ATP) and competes with the natural ATP substrate for incorporation into nascent RNA chains by the SARS-CoV-2 RNA-dependent RNA polymerase, which results in delayed chain termination during replication of the viral RNA. Remdesivir triphosphate is a weak inhibitor of mammalian DNA and RNA polymerases with low potential for mitochondrial toxicity.

Try our Naplex QBank. www.pharmacyexam.com **Please note: This type of question will not show up in an MPJE. We are just posting to MPJE group for knowledge.





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