The transition from mild/moderate symptoms to more severe stages of COVID-19 is marked by the onset of:

a. Loss of or reductions in smell or taste
b. Multi organ failures
c. Severe seizure
d. Acute respiratory distress syndrome
e. Refractory, nonproductive cough

Answer:(d). About 5% of patients with COVID-19 (one-fourth of those needing hospitalization) present with advanced symptoms or become critically ill as viral damage in the lungs results in acute respiratory distress syndrome. Multi-organ failure occurs later in the disease course; changes in smell and taste and nonproductive cough are early symptoms of COVID-19.

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