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What is the probable mechanism of action of Sirturo (Bedaquiline)?

a. Inhibits 5-alpha azo reductase
b. Inhibits DNA gyrase
c. Inhibits mycobacterial ATP synthase
d. Inhibits RNA polymerase
e. Inhibits CGAP ligase

Answer: c

The active ingredient found in Sirturo is Bedaquiline. is the first anti-TB drug to interfere with bacterial energy metabolism.

Sirturo (Bedaquiline)® specifically inhibits mycobacterial ATP (adenosine 5'-triphosphate) synthase, by binding to subunit c of the enzyme that is essential for the generation of energy in Mycobacterium tuberculosis.

Sirturo (Bedaquiline)® is a diarylquinoline antimycobacterial drug indicated as part of combination therapy in the treatment of adult and pediatric patients (12 to less than 18 years of age and weighing at least 30 kg) with pulmonary multi-drug resistant tuberculosis (MDR-TB).

Reserve Sirturo (Bedaquiline)® for use when an effective treatment regimen cannot otherwise be provided. Try our Naplex Questions QBank.