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Which of the following information is/are TRUE about Epidiolex? [Select All That Apply]
a. It is a prescription medicine that is used to treat seizures associated with Lennox-Gastaut syndrome in patients 2 years of age and older.
b. An active ingredient found in Epidiolex is Cannabidiol.
c. It is the first and Only FDA-Approved Prescription CBD.
d. The recommended starting dosage is 20 mg/kg taken twice daily.
e. It can cause transaminase elevations.
Answer: (a, b, c and e).
Epidiolex (Cannabidiol) is a prescription medicine that is used to treat seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients 2 years of age and older.
It is not known if Epidiolex (Cannabidiol) is safe and effective in children under 2 years of age. The active ingredient found in Epidiolex (Cannabidiol) is Cannabidiol.
It is the first and Only FDA-Approved Prescription Cannabidiol (CBD).
The recommended starting dosage is 2.5 mg/kg (Not 20 mg/kg) taken twice daily (5 mg/kg/day). After one week, the dosage can be increased to a maintenance dosage of 5 mg/kg twice daily (10 mg/kg/day).
Epidiolex (Cannabidiol) can cause transaminase elevations. Concomitant use of valproate and higher doses of Epidiolex (Cannabidiol) increase the risk of transaminase elevations. The therapy should be monitored by regularly checking serum transaminases (ALT and AST) and total bilirubin levels.
The most common side effects of Epidiolex (Cannabidiol) include sleepiness, decreased appetite, diarrhea, increase in liver enzymes, feeling very tired and weak, rash, sleep problems, and infections.
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