Lynparza (Olaparib) is indicated for treatment(s) of:
I. Ovarian Cancer
II. Metastatic Breast Cancer
III. Pancreatic cancer
a. I only
b. III only
c. I and II only
d. II and III only
Answer: (e). All. Lynparza (Olaparib) is an inhibitor of the mammalian polyadenosine 5'-diphosphoribose polymerase (PARP) enzyme. Lynparza (Olaparib) tablets for oral administration contain 100 mg or 150 mg of Olaparib.
It is indicated for treatments of:
1. First-Line Maintenance Treatment Of BRCA-Mutated Advanced Ovarian Cancer
2. Maintenance Treatment Of Recurrent Ovarian Cancer
3. Advanced gBRCA-Mutated Ovarian Cancer After 3 Or More Lines Of Chemotherapy
4. Germline BRCA-Mutated HER2-Negative Metastatic Breast Cancer
5. Maintenance Treatment Of gBRCA-Mutated Pancreatic cancer
The recommended dose of Lynparza (Olaparib) is 300 mg (two 150 mg tablets) taken orally twice daily, with or without food, for a total daily dose of 600 mg.
Myelodysplastic Syndrome, Acute Myeloid Leukemia, Pneumonitis, fatigue, nausea, vomiting and fatal toxicity are reported side effects of drug.
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