In a patient taking Erythromycin, the dose of Livalo should be restricted to:
a. 1 mg per day.
b. 5 mg per day.
c. 10 mg per day.
d. 25 mg per day.
e. 50 mg per day.
Answer: a. Pitavastatin (Livalo) is an inhibitor of HMG-CoA reductase. It is a synthetic lipid-lowering agent for oral administration. Each film-coated tablet of Pitavastatin (Livalo) contains1 mg. 2 mg or 4 mg Pitavastatin.
It is indicated as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia.
Doses of Pitavastatin (Livalo) greater than 4 mg once daily were associated with an increased risk for severe myopathy in premarketing clinical studies. PAtients should not exceed 4 mg once daily dosing of Pitavastatin (Livalo). The dose range for Pitavastatin (Livalo) is 1 to 4 mg orally once daily at any time of the day with or without food. The recommended starting dose is 2 mg and the maximum dose is 4 mg.
In patients taking erythromycin, a dose of Pitavastatin (Livalo) 1 mg once daily should not be exceeded. In patients taking rifampin, a dose of Pitavastatin (Livalo) 2 mg once daily should not be exceeded.
Rhabdomyolysis with myoglobinuria and acute renal failure and myopathy (including myositis) and liver enzyme abnormalities are principal side effects of Pitavastatin (Livalo).
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