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Reference Guide For Pharmacy licensing Exam-Questions and Answers-Second Edition (NAPLEX)

Answers

1.(e) The active ingredient of Fibercon is Calcium polycarbophil. It is indicated for constipation as well as diarrhea. Its water absorbing properties make it useful in treatment of diarrhea. It should be taken with plenty of water.

It forms chelation when given with tetracycline antibiotic. Polycarbophil’s water and bile salt binding capacity may result in bulkier solid stool. Polycarbophil is available as a chewable tablet that absorbs up to 60 times its weight of water. Prescription for a Polycarbophil can be filled by Fibercon, Equalactin or by Mitrolan.

2. (e)

3. (e) Duragesic (Fentanyl) transdermal system is available in 25 mcg, 50 mcg, 75 mcg and 100 mcg/hr strength.

Because serious or life-threatening hypoventilation could occur, Duragesic cannot be used for treatment of mild to intermittent pain or in dose exceeding 25 mcg/hr at the initiation of therapy. It is a schedule II control drugs. Duragesic may be worn continuously for 72 hours. If analgesia for more than 72 hours is required, a new system should be applied.

4. (c) Bactroban (Mupirocin 2%) ointment is indicated for treatment of impetigo caused by staphylococcus aureus, B hemolytic streptococcus, and streptococcus pyrogen.

5. (e) The active ingredient of Enulose, Constulose and Duphalac is Lactulose. It is useful in treatment of hyperammonia.

Lactulose is generally degraded in colon by colonic bacteria in low molecular weight organic acid. Acidification of colonic content by this organic acid result in trapping of ammonia as ammonium ion in colon. The osmotic laxative action of Lactulose helps in the excretion of ammonium ion from the colon in feces.

6. (c) Tinactin (Tolnafate) and Desenex extrastrength (Tolnafate) are antifungal agents useful in treatment of athlete’s foot infection. Alphagan is an opthalamic drop indicated for ocular hypertension.

7. (c) Propranolol is a non-selective Beta-1 and Beta-2 blocker. When it is used for treatment of arrhythmia, embolism generally occurs upon restoration of normal rhythm. It masks the symptoms of hypoglycemia.

8. (c) Blood serum concentration of epinephrine and norepinephrine is generally found to be elevated in patients with pheochromocytoma. Pheochromocytoma is generally defined as an adrenal medulla cancer in which a large amount of noradrenaline and adrenaline secrete from the adrenal medulla.

9. (c) Beta blocker and diuretic are first line agents for treatment of hypertension. Ca-channel blocker and Ace inhibitor are indicated when b blocker and diuretic therapy don’t produce any satisfactory results.

10. (e) The elevation of blood pressure may be due to any of the following reason. Patients was not taking Inderal for last couple of days, which contributed to an elevation of his blood pressure due to withdrawal symptoms of drug.

Patients was taking Sudafed (Pseudoephedrine) for treatment of his cold. Sudafed has a Alpha-1 stimulating properties that might contribute to an elevation of patients’s blood pressure.

11. (b) Catapres (Clonidine) has a high tendency to extravagate the depression. Patients has past history of depression, therefore he needs to avoid Clonidine as a antihypertensive agent. Aldomet (Methyldopa) and Reserpine may also contribute in worsening the depression. The use of these agents in patients with past or current history of depression may require careful monitoring in the patients.

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